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dc.contributor.authorTran, C.en
dc.contributor.authorKatsikeros, R.en
dc.contributor.authorManton, N.en
dc.contributor.authorKrebs, N.en
dc.contributor.authorHambidge, M.en
dc.contributor.authorButler, R.en
dc.contributor.authorDavidson, G.en
dc.identifier.citationAmerican Journal of Clinical Nutrition, 2011; 94(4):1026-1032en
dc.description.abstract<h4>Background</h4>Celiac disease (CD) is an immunologic enteropathy triggered by the intake of gluten. It is thought that the enteropathy impairs gut function and absorption.<h4>Objective</h4>We assessed the zinc-absorption capacity and small-bowel integrity in children with CD.<h4>Design</h4>Children in whom a diagnosis of CD was considered clinically and either confirmed (n = 16; Marsh score ≥3) or not (n = 22; Marsh score of 0) with a small-bowel biopsy (SBB) were recruited. The fractional absorption of zinc (FAZ) was determined by the administration of an oral (67)Zn dose (2.5 mg) and an intravenous (70)Zn dose (0.2 mg) 2 h before and during the SBB, respectively. Spot urine samples were collected, and zinc isotopic ratios were determined by ion-coupled plasma mass spectrometry. Gut health was assessed by the ingestion of (13)C-sucrose (20 g) after an overnight fast, and breath samples were collected and analyzed by isotope ratio mass spectrometry.<h4>Results</h4>There was no difference in FAZ between children with a Marsh score ≥3 (mean ± SEM: 0.68 ± 0.05) and children with a Marsh score of 0 (0.74 ± 0.05). The exchangeable zinc pool (EZP) was significantly (P < 0.05) lower in children with a Marsh score ≥3 (2.6 ± 0.8 mg/kg) than in children with a Marsh score of 0 (3.8 ± 1.4 mg/kg). Gut function in children with a Marsh score ≥3 (4.5 ± 0.7% cumulative dose recovered at 90 min) was lower than the lower cutoff of a normal gut-function breath test (5.06% cumulative dose recovered at 90 min) but not significantly different from that in children with a Marsh score of 0 (4.9 ± 0.4%). There was a significant (P < 0.01) correlation between zinc absorption and gut function in children with CD.<h4>Conclusions</h4>Zinc absorption did not appear below usual amounts in subjects with CD. Children with CD have impaired gut function that may affect their zinc nutritional status as shown by a smaller EZP. However, the EZP decrease in children with CD was not compared with that in healthy control subjects, and its biological meaning is uncertain.en
dc.description.statementofresponsibilityCuong D Tran, Rosa Katsikeros, Nick Manton, Nancy F Krebs, K Michael Hambidge, Ross N Butler, and Geoff P Davidsonen
dc.publisherAmer Soc Clinical Nutritionen
dc.rights© 2011 American Society for Nutritionen
dc.subjectIntestine, Small; Humans; Celiac Disease; Deficiency Diseases; Zinc; Carbon Isotopes; Zinc Isotopes; Sucrose; Breath Tests; Biopsy; Severity of Illness Index; Homeostasis; Intestinal Absorption; Algorithms; Adolescent; Child; Child, Preschool; South Australia; Female; Maleen
dc.titleZinc homeostasis and gut function in children with celiac diseaseen
dc.typeJournal articleen
pubs.library.collectionPaediatrics publicationsen
dc.identifier.orcidTran, C. [0000-0001-9220-2715]en
Appears in Collections:Paediatrics publications

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