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dc.contributor.authorVakulin, A.-
dc.contributor.authorBaulk, S.-
dc.contributor.authorCatcheside, P.-
dc.contributor.authorAntic, N.-
dc.contributor.authorvan den Heuvel, C.-
dc.contributor.authorDorrian, J.-
dc.contributor.authorMcEvoy, R.-
dc.identifier.citationThe Journal of Clinical Sleep Medicine, 2011; 7(3):246-253-
dc.description.abstractStudy Objectives: To assess the effectiveness of CPAP treat¬ment in improving 90-minute driving simulator performance in severe OSA patients compared to age/gender matched con¬trols. Design: Driving simulator performance was assessed at base-line and 3 months later, with OSA patients treated with CPAP during the interval. Setting: University Teaching Hospital. Participants: Patients with severe OSA (n = 11) and control subjects without OSA (n = 9). Interventions: CPAP Measurements and Results: Simulator driving parameters of steering deviation, braking reaction time and crashes were measured at baseline and ~3 months follow-up. At baseline, OSA subjects demonstrated significantly greater steering de¬viation compared to controls (mean [95% CI], OSA group, 49.9 cm [43.7 to 56.0 cm] vs control group, 34.9 cm [28.1 to 41.7 cm], p = 0.003). Following ~3 months of CPAP treatment (mean ± SD 6.0 ± 1.4 h/night), steering deviation in OSA subjects improved by an average of 3.1 cm (CI, 1.4 to 4.9), p < 0.001, while no significant steering changes were observed in the control group. Despite the improvement, steering deviation in the OSA group remained significantly higher than in controls (OSA group, 46.7 cm [CI, 40.6 to 52.8 cm] vs control group, 36.1 cm [CI, 29.3 to 42.9 cm], p = 0.025). Conclusions: While driving simulator performance improved after ~3 months of CPAP treatment with high adherence in patients with severe OSA, performance remained impaired compared to control subjects. These results add to the grow¬ing body of evidence that some neurobehavioral deficits in patients with severe OSA are not fully reversed by treatment. Further studies are needed to assess causes of residual driv¬ing simulator impairment and to determine whether this is as¬sociated with persistent elevated real-life accident risk.-
dc.description.statementofresponsibilityAndrew Vakulin, Stuart D. Baulk, Peter G. Catcheside; Nick A. Antic, Cameron J. van den Heuvel, Jillian Dorrian and R. Doug McEvoy-
dc.publisherThe American Academy of Sleep Medicine-
dc.rightsCopyright status unknown-
dc.subjectdriving performance-
dc.titleDriving simulator performance remains impaired in patients with severe OSA after CPAP treatment-
dc.typeJournal article-
dc.identifier.orcidCatcheside, P. [0000-0002-9372-6788]-
dc.identifier.orcidvan den Heuvel, C. [0000-0001-7264-4655]-
dc.identifier.orcidMcEvoy, R. [0000-0002-5759-0094]-
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