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Type: Journal article
Title: Calcitonin receptors, bone sialoprotein and osteopontin are expressed in primary breast cancers
Author: Gillespie, M.
Thomas, R.
Pu, Z.Y.
Zhou, H.
Findlay, D.
Citation: International Journal of Cancer, 1997; 73(6):812-815
Publisher: Wiley
Issue Date: 1997
ISSN: 0020-7136
Statement of
Matthew T. Gillespie, Rachel J. Thomas, Zhao-Yan Pu, Hong Zhou, T. John Martin, David M. Findlay
Abstract: Several human breast cancer cell lines express the calcitonin receptor (CTR), but this has not been demonstrated previously in clinical breast cancers. We examined 18 primary breast cancers by reverse transcription-PCR, for expression of CTR and of the bone proteins osteopontin (OPN) and bone sialoprotein (BSP). OPN and CTR were expressed by each of the tumours, and 7 (39%) additionally expressed an alternate form of CTR, whilst BSP was expressed by 13 tumours (72%). In situ hybridisation confirmed that expression of OPN and CTR was confined to the tumour cells. Expression of CTR, BSP and OPN may prove to be a useful marker for breast cancers, and their role in the homing of breast cancer cells to bone remains to be investigated.
Keywords: Tumor Cells, Cultured
Carcinoma, Ductal, Breast
Breast Neoplasms
Receptors, Calcitonin
RNA, Messenger
In Situ Hybridization
Polymerase Chain Reaction
Integrin-Binding Sialoprotein
Rights: © 1997 Wiley-Liss, Inc.
DOI: 10.1002/(SICI)1097-0215(19971210)73:6<812::AID-IJC7>3.0.CO;2-5
Appears in Collections:Aurora harvest
Orthopaedics and Trauma publications

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