Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/67150
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Type: Journal article
Title: Antimicrobial susceptibilities of commonly encountered bacterial isolates to fosfomycin determined by agar dilution and disk diffusion methods
Author: Lu, C.
Liu, C.
Huang, Y.
Liao, C.
Teng, L.
Turnidge, J.
Hsueh, P.
Citation: Antimicrobial Agents and Chemotherapy, 2011; 55(9):4295-4301
Publisher: Amer Soc Microbiology
Issue Date: 2011
ISSN: 0066-4804
1098-6596
Statement of
Responsibility: 
Ching-Lan Lu, Chia-Ying Liu, Yu-Tsung Huang, Chun-Hsing Liao, Lee-Jene Teng, John D. Turnidge and Po-Ren Hsueh
Abstract: We studied the antimicrobial activity of fosfomycin against 960 strains of commonly encountered bacteria associated with urinary tract infection using standard agar dilution and disk diffusion methods. Species studied included 3 common species of Enterobacteriaceae, Pseudomonas aeruginosa, Acinetobacter baumannii, and Stenotrophomonas maltophilia; methicillin-susceptible and -resistant Staphylococcus aureus; and vancomycin-susceptible and resistant Enterococcus faecalis and E. faecium. MICs and inhibition zone diameters were interpreted in accordance with both the currently recommended Clinical and Laboratory Standards Institute (CLSI) criteria for urinary tract isolates of Escherichia coli and Enterococcus faecalis and the European Committee on Antimicrobial Susceptibility Testing (EUCAST) criteria for Enterobacteriaceae. Tentative zone diameter interpretive criteria were developed for species not currently published by CLSI or EUCAST. Escherichia coli was uniformly susceptible to fosfomycin, as were most strains of Klebsiella pneumoniae and Enterobacter cloacae. A. baumannii was resistant to fosfomycin, while the prevalence of resistance in P. aeruginosa and S. maltophilia was greatly affected by the choice of MIC breakpoint. New tentative zone diameter criteria for K. pneumoniae, E. cloacae, S. aureus, and E. faecium were able to be set, providing some interim laboratory guidance for disk diffusion until further breakpoint evaluations are undertaken by CLSI and EUCAST.
Keywords: Acinetobacter baumannii; Pseudomonas aeruginosa; Enterobacteriaceae; Staphylococcus aureus; Enterococcus faecalis; Fosfomycin; Anti-Bacterial Agents; Microbial Sensitivity Tests; Methicillin-Resistant Staphylococcus aureus
Rights: Copyright © 2011, American Society for Microbiology. All Rights Reserved.
RMID: 0020112195
DOI: 10.1128/AAC.00349-11
Appears in Collections:Microbiology and Immunology publications

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