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dc.contributor.authorTurner, R.en
dc.contributor.authorHelps, S.en
dc.contributor.authorThornton, E.en
dc.contributor.authorVink, R.en
dc.identifier.citationBrain Research, 2011; 1393:84-90en
dc.description.abstractPrevious studies have suggested that substance P (SP) plays a critical role in the development of brain oedema and functional deficits following traumatic brain injury and that SP receptor antagonism may improve outcome. No studies have described such a role in ischemic stroke. The present study characterized the effects of the NK1 tachykinin receptor antagonist, n-acetyl-L-tryptophan (NAT), on blood-brain barrier (BBB) breakdown, oedema formation, infarct volume and functional outcome following reversible ischemic stroke in rats. Ischemia was induced using a reversible thread model of middle cerebral artery occlusion where occlusion was maintained for 2 h before reperfusion. Animals received either NAT or equal volume saline vehicle intravenously at 2 h post-reperfusion. Ischaemic stroke resulted in increased perivascular SP immunoreactivity at 24 h. Administration of NAT significantly reduced oedema formation and BBB permeability at 24 h post-ischemia and significantly improved functional outcome as assessed over 7 days. There was no effect on infarct volume. We conclude that inhibition of SP activity with a NK1 tachykinin receptor antagonist is effective in reducing cerebral oedema, BBB permeability and functional deficits following reversible ischemia and may therefore represent a novel therapeutic approach to the treatment of ischaemic stroke.en
dc.description.statementofresponsibilityRenée J. Turner, Stephen C. Helps, Emma Thornton and Robert Vinken
dc.publisherElsevier Science Bven
dc.rights© 2011 Elsevier B.V. All rights reserved.en
dc.subjectIschaemic stroke; NK1 tachykinin receptor antagonist; Oedema; Neuropeptides; Neurogenic inflammationen
dc.titleA substance P antagonist improves outcome when administered 4 h after onset of ischaemic strokeen
dc.typeJournal articleen
pubs.library.collectionMedical Sciences publicationsen
dc.identifier.orcidTurner, R. [0000-0003-4278-8302]en
dc.identifier.orcidVink, R. [0000-0002-4885-0667]en
Appears in Collections:Medical Sciences publications

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