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Type: Journal article
Title: Endothelial function is impaired after a high-salt meal in healthy subjects
Author: Dickinson, K.
Clifton, P.
Keogh, J.
Citation: American Journal of Clinical Nutrition, 2011; 93(3):500-505
Publisher: Amer Soc Clinical Nutrition
Issue Date: 2011
ISSN: 0002-9165
Statement of
Kacie M Dickinson, Peter M Clifton, and Jennifer B Keogh
Abstract: Background: Dietary salt is related to blood pressure (BP), and cardiovascular disease and increased sodium intakes have been shown to impair vascular function. The effect of salt on endothelial function postprandially is unknown. Objective: The aim was to investigate the postprandial effect of dietary salt on endothelial function as measured by flow-mediated dilatation (FMD) and peripheral arterial tonometry in healthy subjects. Design: Sixteen healthy, normotensive subjects received a meal with added salt (HSM; 65 mmol Na) and a control low-salt meal (LSM; 5 mmol Na) on 2 separate occasions in a randomized order. Endothelial function was measured while fasting and postprandially at 30, 60, 90, and 120 min by using FMD and reactive hyperemia peripheral arterial tonometry. BP was also measured. Results: Baseline FMD, reactive hyperemia index (RHI), and BP values were similar across interventions. Overall FMD was reduced 2 h postprandially. FMD was significantly more impaired after the HSM than after the LSM at 30 min [HSM (mean ± SD): 3.39 ± 2.44%; LSM: 6.05 ± 3.21%; P < 0.01] and at 60 min (HSM: 2.20 ± 2.77%; LSM: 4.64 ± 2.48%; P < 0.01). No significant differences in BP or RHI were observed between meals. Conclusions: An HSM, which reflects the typical amount of salt consumed in a commonly eaten meal, can significantly suppress brachial artery FMD within 30 min. These results suggest that high salt intakes have acute adverse effects on vascular dilatation in the postprandial state. This trial was registered at as ACTRN12610000124033.
Keywords: Brachial Artery
Endothelium, Vascular
Sodium Chloride, Dietary
Diet, Sodium-Restricted
Severity of Illness Index
Blood Pressure
Postprandial Period
Middle Aged
Young Adult
Rights: © 2011 American Society for Nutrition
DOI: 10.3945/ajcn.110.006155
Appears in Collections:Aurora harvest
Medicine publications

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