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https://hdl.handle.net/2440/67273
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dc.contributor.author | van der Pol, R. | - |
dc.contributor.author | Smits, M. | - |
dc.contributor.author | van Wijk, M. | - |
dc.contributor.author | Omari, T. | - |
dc.contributor.author | Tabbers, M. | - |
dc.contributor.author | Benninga, M. | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Pediatrics, 2011; 127(5):925-935 | - |
dc.identifier.issn | 0031-4005 | - |
dc.identifier.issn | 1098-4275 | - |
dc.identifier.uri | http://hdl.handle.net/2440/67273 | - |
dc.description.abstract | <h4>Introduction</h4>Use of proton-pump inhibitors (PPIs) for the treatment of gastroesophageal reflux disease (GERD) in children has increased enormously. However, effectiveness and safety of PPIs for pediatric GERD are under debate.<h4>Objectives</h4>We performed a systematic review to determine effectiveness and safety of PPIs in children with GERD.<h4>Methods</h4>We searched PubMed, Embase, and the Cochrane Database of Systematic Reviews for randomized controlled trials and crossover studies investigating efficacy and safety of PPIs in children aged 0 to 18 years with GERD for reduction in GERD symptoms, gastric pH, histologic aberrations, and reported adverse events.<h4>Results</h4>Twelve studies were included with data from children aged 0-17 years. For infants, PPIs were more effective in 1 study (compared with hydrolyzed formula), not effective in 2 studies, and equally effective in 2 studies (compared with placebo) for the reduction of GERD symptoms. For children and adolescents, PPIs were equally effective (compared with alginates, ranitidine, or a different PPI dosage). For gastric acidity, in infants and children PPIs were more effective (compared with placebo, alginates, or ranitidine) in 4 studies. For reducing histologic aberrations, PPIs showed no difference (compared with ranitidine or alginates) in 3 studies. Six studies reported no differences in treatment-related adverse events (compared with placebo or a different PPI dosage).<h4>Conclusions</h4>PPIs are not effective in reducing GERD symptoms in infants. Placebo-controlled trials in older children are lacking. Although PPIs seem to be well tolerated during short-term use, evidence supporting the safety of PPIs is lacking. | - |
dc.description.statementofresponsibility | Rachel J. van der Pol, Marije J. Smits, Michiel P. van Wijk, Taher I. Omari, Merit M. Tabbers and Marc A. Benninga | - |
dc.language.iso | en | - |
dc.publisher | Amer Acad Pediatrics | - |
dc.rights | Copyright © 2011 by the American Academy of Pediatrics | - |
dc.source.uri | http://dx.doi.org/10.1542/peds.2010-2719 | - |
dc.subject | systematic review | - |
dc.subject | gastroesophageal reflux disease | - |
dc.subject | efficacy | - |
dc.subject | safety | - |
dc.subject | proton-pump inhibitors | - |
dc.subject | children | - |
dc.title | Efficacy of proton-pump inhibitors in children with gastroesophageal reflux disease: A systematic review | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1542/peds.2010-2719 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Omari, T. [0000-0001-5108-7378] | - |
Appears in Collections: | Aurora harvest 5 Paediatrics publications |
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