Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/67275
Citations
Scopus Web of Science® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorThompson, S.en
dc.contributor.authorBartholomeusz, D.en
dc.contributor.authorJamieson, G.en
dc.date.issued2011en
dc.identifier.citationJournal of Gastrointestinal Surgery, 2011; 15(10):1762-1768en
dc.identifier.issn1091-255Xen
dc.identifier.issn1873-4626en
dc.identifier.urihttp://hdl.handle.net/2440/67275-
dc.description.abstract<h4>Introduction</h4>Sentinel node mapping is established in some superficial cancers but remains controversial in harder-to-access solid tumors. There are an increasing number of recent studies suggesting that isolated tumor cells have prognostic significance in predicting poor survival, in breast cancer, esophageal cancer, and others. It is for this reason that we have persevered with the sentinel lymph node concept in our esophagectomy cancer patients, and we report our results since 2008.<h4>Methods</h4>Thirty-one of 32 consecutive patients underwent resection for invasive esophageal cancer along with sentinel lymph node retrieval (resection rate, 97%). Peritumoral injection of (99m)Tc antimony colloid was performed by upper endoscopy prior to the operation. A two-surgeon synchronous approach via a right thoracotomy and laparotomy was performed with a conservative lymphadenectomy. Sentinel lymph nodes were identified with a gamma probe both in and ex vivo, and sent off separately for three serial sections and immunohistochemistry with AE1/AE3.<h4>Results</h4>The median patient age was 63.4 years (range, 45-75 years). Most patients (81%) had an adenocarcinoma, and 61% had received neoadjuvant therapy. At least one sentinel lymph node (median, 3) was identified in 29 of 31 patients (success rate, 94%). Sentinel nodes were present in more than one nodal station in 16 patients (55%). One false negative case led to a sensitivity of 90%. In 28 of 29 patients, the sentinel lymph node accurately predicted findings in non-sentinel nodes (accuracy, 96%).<h4>Conclusions</h4>Sentinel lymph node biopsy is both feasible and accurate in esophageal resections with conservative lymphadenectomy. It allows targeted serial sectioning and immunohistochemical studies of those nodes and should become standard of care in patients undergoing esophagectomy for esophageal cancer.en
dc.description.statementofresponsibilitySarah K. Thompson, Dylan Bartholomeusz, Glyn G. Jamiesonen
dc.language.isoenen
dc.publisherElsevier Svience Incen
dc.rights© 2011 The Society for Surgery of the Alimentary Tracten
dc.subjectSentinel lymph node; Esophageal cancer; Esophagectomy; Lymphoscintigraphy; Immunohistochemistry; Lymph nodeen
dc.titleSentinel lymph node biopsy in esophageal cancer: Should it be standard of care?en
dc.typeJournal articleen
dc.identifier.rmid0020112972en
dc.identifier.doi10.1007/s11605-011-1634-3en
dc.identifier.pubid27611-
pubs.library.collectionSurgery publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Surgery publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.