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Type: Journal article
Title: The emerging role of hypoxia, HIF-1 and HIF-2 in multiple myeloma
Author: Martin, S.
Diamond, P.
Gronthos, S.
Peet, D.
Zannettino, A.
Citation: Leukemia, 2011; 25(10):1533-1542
Publisher: Nature Publishing Group
Issue Date: 2011
ISSN: 0887-6924
Statement of
SK Martin, P Diamond, S Gronthos, DJ Peet and ACW Zannettino
Abstract: Hypoxia is an imbalance between oxygen supply and demand, which deprives cells or tissues of sufficient oxygen. It is well-established that hypoxia triggers adaptive responses, which contribute to short- and long-term pathologies such as inflammation, cardiovascular disease and cancer. Induced by both microenvironmental hypoxia and genetic mutations, the elevated expression of the hypoxia-inducible transcription factor-1 (HIF-1) and HIF-2 is a key feature of many human cancers and has been shown to promote cellular processes, which facilitate tumor progression. In this review, we discuss the emerging role of hypoxia and the HIFs in the pathogenesis of multiple myeloma (MM), an incurable hematological malignancy of BM PCs, which reside within the hypoxic BM microenvironment. The need for current and future therapeutic interventions to target HIF-1 and HIF-2 in myeloma will also be discussed.
Keywords: multiple myeloma; hypoxia; HIF-1; HIF-2
Rights: © 2011 Macmillan Publishers Limited. All rights reserved.
RMID: 0020113611
DOI: 10.1038/leu.2011.122
Appears in Collections:Medicine publications

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