Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/6780
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dc.contributor.authorRogers, S.en
dc.contributor.authorHowie, D.en
dc.contributor.authorGraves, S.en
dc.contributor.authorPearcy, M.en
dc.contributor.authorHaynes, D.en
dc.date.issued1997en
dc.identifier.citationJournal of Bone and Joint Surgery (British), 1997; 79-B(2):311-315en
dc.identifier.issn0301-620Xen
dc.identifier.issn2044-5377en
dc.identifier.urihttp://hdl.handle.net/2440/6780-
dc.description.abstractOur aim was to determine whether in vitro studies would detect differences in the cellular response to wear particles of two titanium alloys commonly used in the manufacture of joint replacement prostheses. Particles were of the order of 1 microm in diameter representative of those found adjacent to failed prostheses. Exposure of human monocytes to titanium 6-aluminium 4- vanadium (TiAlV) at concentrations of 4 x 10(7) particles/ml produced a mean prostaglandin E2 release of 2627.6 pM; this was significantly higher than the 317.4 pM induced by titanium 6-aluminium 7-niobium alloy (TiAlNb) particles (p = 0.006). Commercially-pure titanium particles induced a release of 347.8 pM. In addition, TiAlV stimulated significantly more release of the other cell mediators, interleukin-1, tumour necrosis factor and interleukin-6. At lower concentrations of particles there was less mediator release and less obvious differences between materials. None of the materials caused significant toxicity. The levels of inflammatory mediators released by phagocytic cells in response to wear particles may influence the amount of periprosthetic bone loss. Our findings have shown that in vitro studies can detect differences in cellular response induced by particles of similar titanium alloys in common clinical use, although in vivo studies have shown little difference. While in vitro studies should not be used as the only form of assessment, they must be considered when assessing the relative biocompatibility of different implant materials.en
dc.description.statementofresponsibilityS. D. Rogers, D. W. Howie, S. E. Graves, M. J. Pearcy, D. R. Haynesen
dc.description.urihttp://www.bjj.boneandjoint.org.uk/content/79-B/2/311en
dc.language.isoenen
dc.publisherBRITISH EDITORIAL SOC BONE JOINT SURGERYen
dc.subjectMonocytes; Cells, Cultured; Humans; Titanium; Alloys; Dinoprostone; Tumor Necrosis Factor-alpha; Interleukin-1; Interleukin-6; Suspensions; Microscopy, Electron, Scanning; Radioimmunoassay; Materials Testing; Joint Prosthesis; Particle Sizeen
dc.titleIn vitro human monocyte response to wear particles of titanium alloy containing vanadium or niobiumen
dc.typeJournal articleen
dc.identifier.rmid0030005817en
dc.identifier.doi10.1302/0301-620X.79B2.7192en
dc.identifier.pubid69823-
pubs.library.collectionOrthopaedics and Trauma publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidHowie, D. [0000-0003-1702-3279]en
Appears in Collections:Orthopaedics and Trauma publications

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