Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/68227
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Type: Journal article
Title: Safety of rapid rituximab infusion in adult cancer patients: A systematic review
Author: Lang, S.
Hagger, J.
Pearson, A.
Citation: International Journal of Nursing Practice, 2011; 17(4):357-369
Publisher: Blackwell Science Asia Pty Ltd
Issue Date: 2011
ISSN: 1322-7114
1440-172X
Statement of
Responsibility: 
Dora SP Lang, Christina Hagger, Alan Pearson
Abstract: The purpose of this study is to critically appraise, synthesize and present the best available evidence related to the safety of rapid rituximab infusion in adult non-Hodgkin lymphoma and chronic lymphocytic leukaemia patients. Data are from published and unpublished studies from electronic databases, grey literature and reference lists. The studies that met the inclusion criteria were critically appraised by two independent reviewers for methodological validity using standardized critical appraisal instruments. Proportional meta-analysis based on DerSimonian–Laird weights using a random effects model was used for statistical pooling through Stats Direct. Heterogeneity is assessed using Cochran Q. When statistical pooling is not possible, the findings were presented in narrative summary. Rapid rituximab infusion is safe for non-Hodgkin lymphoma patients at a 90 min regimen. However, there is insufficient evidence to support rapid rituximab infusions for chronic lymphocytic leukaemia patients.
Keywords: infusion; leukaemia; lymphoma; review; rituximab.
Rights: © 2011 Blackwell Publishing Asia Pty Ltd.
RMID: 0020111259
DOI: 10.1111/j.1440-172X.2011.01950.x
Appears in Collections:Nursing publications

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