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|Title:||Early-life origins of metabolic dysfunction: role of the adipocyte|
|Citation:||Trends in Endocrinology and Metabolism, 2009; 20(2):51-57|
|Publisher:||Elsevier Science London|
|Beverly Muhlhausler and Steven R. Smith|
|Abstract:||More than 60% of adults in the US are classified as overweight, with most developing associated metabolic problems. It is increasingly clear that the origins of obesity and metabolic disease are early in life, yet the physiological basis for this is not well understood. We propose that perturbations to nutrient supply in utero affect adipocyte development, altering functional properties and promoting excess body fat accumulation after birth. We also propose that excessive body fat accumulation leads to leptin and insulin resistance in these individuals, rendering them more susceptible to further weight gain and metabolic deterioration. Finally, we propose that interventions that inhibit this early increase in fat deposition have the potential to interrupt the pathway to obesity.|
|Keywords:||Adipocytes; Animals; Humans; Diabetes, Gestational; Fetal Nutrition Disorders; Metabolic Diseases; Insulin Resistance; Child Development; Embryonic Development; Pregnancy; Models, Biological; Infant, Newborn; Female; Intra-Abdominal Fat|
|Rights:||Copyright © 2008 Elsevier Ltd. All rights reserved.|
|Appears in Collections:||Agriculture, Food and Wine publications|
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