Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/68280
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Early-life origins of metabolic dysfunction: role of the adipocyte
Author: Muhlhausler, B.
Smith, S.
Citation: Trends in Endocrinology and Metabolism, 2009; 20(2):51-57
Publisher: Elsevier Science London
Issue Date: 2009
ISSN: 1043-2760
1879-3061
Statement of
Responsibility: 
Beverly Muhlhausler and Steven R. Smith
Abstract: More than 60% of adults in the US are classified as overweight, with most developing associated metabolic problems. It is increasingly clear that the origins of obesity and metabolic disease are early in life, yet the physiological basis for this is not well understood. We propose that perturbations to nutrient supply in utero affect adipocyte development, altering functional properties and promoting excess body fat accumulation after birth. We also propose that excessive body fat accumulation leads to leptin and insulin resistance in these individuals, rendering them more susceptible to further weight gain and metabolic deterioration. Finally, we propose that interventions that inhibit this early increase in fat deposition have the potential to interrupt the pathway to obesity.
Keywords: Adipocytes; Animals; Humans; Diabetes, Gestational; Fetal Nutrition Disorders; Metabolic Diseases; Insulin Resistance; Child Development; Embryonic Development; Pregnancy; Models, Biological; Infant, Newborn; Female; Intra-Abdominal Fat
Rights: Copyright © 2008 Elsevier Ltd. All rights reserved.
RMID: 0020108830
DOI: 10.1016/j.tem.2008.10.006
Appears in Collections:Agriculture, Food and Wine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.