Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/68519
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Type: Journal article
Title: High-dose docosahexaenoic acid supplementation of preterm infants: Respiratory and allergy outcomes
Author: Manley, B.
Makrides, M.
Collins, C.
McPhee, A.
Gibson, R.
Ryan, P.
Sullivan, T.
Davis, P.
Citation: Pediatrics, 2011; 128(1):E71-E77
Publisher: Amer Acad Pediatrics
Issue Date: 2011
ISSN: 0031-4005
1098-4275
Statement of
Responsibility: 
Brett J. Manley, Maria Makrides, Carmel T. Collins, Andrew J. McPhee, Robert A. Gibson, Philip Ryan, Thomas R. Sullivan, and Peter G. Davis for the DINO Steering Committee
Abstract: BACKGROUND: Docosahexaenoic acid (DHA) has been associated with downregulation of inflammatory responses. OBJECTIVE: To report the effect of DHA supplementation on long-term atopic and respiratory outcomes in preterm infants. METHODS: This study is a multicenter, randomized controlled trial comparing the outcomes for preterm infants <33 weeks' gestation who consumed expressed breast milk from mothers taking either tuna oil (high-DHA diet) or soy oil (standard-DHA) capsules. Data collected included incidence of bronchopulmonary dysplasia (BPD) and parental reporting of atopic conditions over the first 18 months of life. RESULTS: Six hundred fifty-seven infants were enrolled (322 to high-DHA diet, 335 to standard), and 93.5% completed the 18-month follow-up. There was a reduction in BPD in boys (relative risk [RR]: 0.67 [95% confidence interval (CI): 0.47–0.96]; P = .03) and in all infants with a birth weight of <1250 g (RR: 0.75 [95% CI: 0.57–0.98]; P = .04). There was no effect on duration of respiratory support, admission length, or home oxygen requirement. There was a reduction in reported hay fever in all infants in the high-DHA group at either 12 or 18 months (RR: 0.41 [95% CI: 0.18–0.91]; P = .03) and at either 12 or 18 months in boys (RR: 0.15 [0.03–0.64]; P = .01). There was no effect on asthma, eczema, or food allergy. CONCLUSIONS: DHA supplementation for infants of <33 weeks' gestation reduced the incidence of BPD in boys and in all infants with a birth weight of <1250 g and reduced the incidence of reported hay fever in boys at either 12 or 18 months.
Keywords: docosahexaenoic acid; allergy; respiratory; premature infants
Rights: Copyright © 2011 by the American Academy of Pediatrics
RMID: 0020111017
DOI: 10.1542/peds.2010-2405
Appears in Collections:Paediatrics publications

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