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https://hdl.handle.net/2440/68519
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dc.contributor.author | Manley, B. | - |
dc.contributor.author | Makrides, M. | - |
dc.contributor.author | Collins, C. | - |
dc.contributor.author | McPhee, A. | - |
dc.contributor.author | Gibson, R. | - |
dc.contributor.author | Ryan, P. | - |
dc.contributor.author | Sullivan, T. | - |
dc.contributor.author | Davis, P. | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Pediatrics, 2011; 128(1):E71-E77 | - |
dc.identifier.issn | 0031-4005 | - |
dc.identifier.issn | 1098-4275 | - |
dc.identifier.uri | http://hdl.handle.net/2440/68519 | - |
dc.description.abstract | BACKGROUND: Docosahexaenoic acid (DHA) has been associated with downregulation of inflammatory responses. OBJECTIVE: To report the effect of DHA supplementation on long-term atopic and respiratory outcomes in preterm infants. METHODS: This study is a multicenter, randomized controlled trial comparing the outcomes for preterm infants <33 weeks' gestation who consumed expressed breast milk from mothers taking either tuna oil (high-DHA diet) or soy oil (standard-DHA) capsules. Data collected included incidence of bronchopulmonary dysplasia (BPD) and parental reporting of atopic conditions over the first 18 months of life. RESULTS: Six hundred fifty-seven infants were enrolled (322 to high-DHA diet, 335 to standard), and 93.5% completed the 18-month follow-up. There was a reduction in BPD in boys (relative risk [RR]: 0.67 [95% confidence interval (CI): 0.47–0.96]; P = .03) and in all infants with a birth weight of <1250 g (RR: 0.75 [95% CI: 0.57–0.98]; P = .04). There was no effect on duration of respiratory support, admission length, or home oxygen requirement. There was a reduction in reported hay fever in all infants in the high-DHA group at either 12 or 18 months (RR: 0.41 [95% CI: 0.18–0.91]; P = .03) and at either 12 or 18 months in boys (RR: 0.15 [0.03–0.64]; P = .01). There was no effect on asthma, eczema, or food allergy. CONCLUSIONS: DHA supplementation for infants of <33 weeks' gestation reduced the incidence of BPD in boys and in all infants with a birth weight of <1250 g and reduced the incidence of reported hay fever in boys at either 12 or 18 months. | - |
dc.description.statementofresponsibility | Brett J. Manley, Maria Makrides, Carmel T. Collins, Andrew J. McPhee, Robert A. Gibson, Philip Ryan, Thomas R. Sullivan, and Peter G. Davis for the DINO Steering Committee | - |
dc.language.iso | en | - |
dc.publisher | Amer Acad Pediatrics | - |
dc.rights | Copyright © 2011 by the American Academy of Pediatrics | - |
dc.source.uri | http://dx.doi.org/10.1542/peds.2010-2405 | - |
dc.subject | docosahexaenoic acid | - |
dc.subject | allergy | - |
dc.subject | respiratory | - |
dc.subject | premature infants | - |
dc.title | High-dose docosahexaenoic acid supplementation of preterm infants: Respiratory and allergy outcomes | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1542/peds.2010-2405 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Makrides, M. [0000-0003-3832-541X] | - |
dc.identifier.orcid | Collins, C. [0000-0003-3308-9948] | - |
dc.identifier.orcid | McPhee, A. [0000-0003-3820-5696] | - |
dc.identifier.orcid | Gibson, R. [0000-0002-8750-525X] | - |
Appears in Collections: | Aurora harvest Paediatrics publications |
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