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Type: Journal article
Title: Immediate and longer term immunogenicity of a single dose of the combined haemophilus influenzae type B-Neisseria meningitidis serogroup C-tetanus toxoid conjugate vaccine in primed toddlers 12 to 18 months of age
Author: Booy, R.
Richmond, P.
Nolan, T.
McVernon, J.
Marshall, H.
Nissen, M.
Reynolds, G.
Ziegler, J.
Heron, L.
Lambert, S.
Caubet, M.
Mesaros, N.
Boutriau, D.
Citation: Pediatric Infectious Disease Journal, 2011; 30(4):340-342
Publisher: Lippincott Williams & Wilkins
Issue Date: 2011
ISSN: 0891-3668
Statement of
Robert Booy, Peter Richmond, Terry Nolan, Jodie McVernon, Helen Marshall, Michael Nissen, Graham Reynolds, John B. Ziegler, Leon Heron, Stephen Lambert, Magalie Caubet, Narcisa Mesaros and Dominique Boutriau
Abstract: Hib-primed but MenC-naive toddlers (N = 433) were randomized to receive 1 dose of Hib-MenC-TT or separate Hib-TT and MenC-CRM197 vaccines. One month later, noninferiority was demonstrated for serum bactericidal anti-MenC antibodies (rSBA) and Hib antipolyribosylribitol phosphate (PRP) antibodies; >99% in both groups had rSBA titer ≥ 8 or anti-PRP concentration ≥ 0.15 μg/mL. After 12 months, rSBA titer ≥ 8 persisted in 86.7% and 76.4%, and anti-PRP concentration ≥ 0.15 μg/mL persisted in 98.8% and 100% of children, respectively.
Keywords: Haemophilus influenzae type b; Neisseria meningitidis serogroup C; antibody persistence; toddlers
Rights: © 2011 Lippincott Williams & Wilkins, Inc.
RMID: 0020104381
DOI: 10.1097/INF.0b013e31820013d2
Appears in Collections:Paediatrics publications

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