Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/6853
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Type: Journal article
Title: The role of polyethylene wear in joint replacement failure
Author: McGee, M.
Howie, D.
Neale, S.
Haynes, D.
Pearcy, M.
Citation: Proceedings of the Institution of Mechanical Engineers, Part H, 1997; 211(1):65-72
Publisher: Institution of Mechanical Engineers
Issue Date: 1997
ISSN: 0954-4119
2041-3033
Statement of
Responsibility: 
M A McGee, D W Howie, S D Neale, D R Haynes and M J Pearcy
Abstract: Aseptic loosening is the major cause of failure of joint replacement prostheses. Polyethylene implants removed at revision regularly show wear. It is proposed that the polyethylene particles released into the tissues as a consequence of this wear induce a tissue response that precedes aseptic loosening. This paper presents the results of recent invivo and inviro studies of the biological response to polyethylene wear particles undertaken in the authors' laboratories. A clinical perspective is provided by the inclusion of the author's recent observations of retrieval analyses of joint replacement implant wear and the tissue response to polyethylene in humans.
Keywords: joint replacement, polyethylene, loosening prosthesis, wear
Rights: © IMechE 1997
RMID: 0030005784
DOI: 10.1243/0954411971534692
Appears in Collections:Orthopaedics and Trauma publications

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