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https://hdl.handle.net/2440/68583
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Type: | Journal article |
Title: | Testosterone and modifiable risk factors associated with diabetes in men |
Author: | Atlantis, E. Lange, K. Martin, S. Haren, M. Taylor, A. O'Loughlin, P. Marshall, V. Wittert, G. |
Citation: | Maturitas, 2011; 68(3 Sp Iss):279-285 |
Publisher: | Elsevier Sci Ireland Ltd |
Issue Date: | 2011 |
ISSN: | 0378-5122 1873-4111 |
Statement of Responsibility: | Evan Atlantis, Kylie Lange, Sean Martin, Matthew T. Haren, Anne Taylor, Peter D. O’Loughlin, Villis Marshall, Gary A. Wittert |
Abstract: | OBJECTIVE: The role of endogenous testosterone in the pathogenesis of type 2 diabetes mellitus remains vague. We investigated whether associations between endogenous testosterone and diabetes prevalence in men could be partially explained by modifiable risk factors. STUDY DESIGN: A random population-based cross-sectional study of 1195 men aged 35-80 years living in the north-west regions of Adelaide, Australia. Data collections occurred between 2002 and 2005, and response rate was 45.1%. MATERIALS AND METHODS: Diabetes (non-specific) was classified by either: (1) self-report for doctor diagnosis of diabetes; (2) prescription medication for diabetes; (3) fasting plasma glucose ≥ 7 mmol/L; or (4) glycosylated haemoglobin ≥ 6.2%. Logistic regressions were used to estimate odds ratios (OR [with 95% confidence intervals]) for diabetes, with stepwise adjustments for demographic, lifestyle, and clinical factors. RESULTS: Diabetes prevalence was positively associated with age groups 45-54 years (2.8 [1.4, 5.8]), 55-64 years (3.9 [1.9, 8.3]) and ≥ 65 years (4.0 [1.8, 8.9]), lowest income group (1.8 [1.0, 3.4]), ex-smoker (1.8 [1.2, 2.9]), lowest (3.2 [1.9, 5.5]) and middle (1.9 [1.1, 3.4]) alcohol tertiles, cardiovascular disease (1.9 [1.2, 2.8]), metabolic syndrome (4.0 [2.6, 6.1]), and lowest plasma total testosterone tertile (1.8 [1.1, 3.0]), but negatively associated with middle (0.5 [0.3, 0.8]) and highest (0.4 [0.3, 0.7]) sugar intake tertiles, arthritis (0.6 [0.3, 1.0]), and elevated LDL cholesterol (0.5 [0.3, 0.8]); ORs showed an inverted 'U' shape for middle and highest voiding lower urinary tract symptoms tertiles. Body composition, muscle strength, and cardio-metabolic factors partially explained the association between low plasma total testosterone and diabetes. CONCLUSIONS: Plasma total testosterone was inversely and independently associated with diabetes prevalence, that might have been partially explained by several modifiable risk factors. |
Keywords: | Testosterone Androgen SHBG Diabetes Hyperglycaemia Glycosylated haemoglobin |
Rights: | Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
DOI: | 10.1016/j.maturitas.2010.12.007 |
Appears in Collections: | Aurora harvest Medicine publications |
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