Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/68636
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Type: Journal article
Title: Dietary protein, weight loss, and weight maintenance
Author: Westerterp-Plantenga, M.
Nieuwenhuizen, A.
Tome, D.
Soenen, S.
Westerterp, K.
Citation: Annual Review of Nutrition, 2009; 29(1):21-41
Publisher: Annual Reviews
Issue Date: 2009
ISSN: 0199-9885
1545-4312
Statement of
Responsibility: 
M.S. Westerterp-Plantenga, A. Nieuwenhuizen, D. Tomé, S. Soenen, and K.R. Westerterp
Abstract: The role of dietary protein in weight loss and weight maintenance encompasses influences on crucial targets for body weight regulation, namely satiety, thermogenesis, energy efficiency, and body composition. Protein-induced satiety may be mainly due to oxidation of amino acids fed in excess, especially in diets with “incomplete” proteins. Protein-induced energy expenditure may be due to protein and urea synthesis and to gluconeogenesis; “complete” proteins having all essential amino acids show larger increases in energy expenditure than do lower-quality proteins. With respect to adverse effects, no protein-induced effects are observed on net bone balance or on calcium balance in young adults and elderly persons. Dietary protein even increases bone mineral mass and reduces incidence of osteoporotic fracture. During weight loss, nitrogen intake positively affects calcium balance and consequent preservation of bone mineral content. Sulphur-containing amino acids cause a blood pressure–raising effect by loss of nephron mass. Subjects with obesity, metabolic syndrome, and type 2 diabetes are particularly susceptible groups. This review provides an overview of how sustaining absolute protein intake affects metabolic targets for weight loss and weight maintenance during negative energy balance, i.e., sustaining satiety and energy expenditure and sparing fat-free mass, resulting in energy inefficiency. However, the long-term relationship between net protein synthesis and sparing fat-free mass remains to be elucidated.
Keywords: satiety
energy expenditure
substrate oxidation
body composition
protein metabolism
Rights: Copyright © 2009 by Annual Reviews. All rights reserved.
DOI: 10.1146/annurev-nutr-080508-141056
Appears in Collections:Aurora harvest 5
Chemical Engineering publications

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