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dc.contributor.authorBazargani, T.en
dc.contributor.authorHemmatzadeh, F.en
dc.contributor.authorNadjafi, J.en
dc.contributor.authorSadeghi Nasab, A.en
dc.identifier.citationIranian Journal of Veterinary Research, 2008; 9(3):271-276en
dc.description.abstractAn outbreak of a lethal disease was reported in 4–6-month-old Holstein calves in a feedlot around Tehran. The signs of central nervous system and gastrointestinal system (GI) involvement were observed in the diseased animals. Necropsy samples of GI, liver, kidney, spleen and lung from 3 died animals were prepared for histopathological examination. Blood and formalin-fixed ear notch samples of 6 calves were submitted for RT-PCR, antigen-capture ELISA (ACE) and immunohistochemistry (IHC) for the detection of BVDV. The results of ACE on buffy coats were negative but RT-PCR of all 6 cases and IHC of 4 cases were positive for BVDV infection. Based on the clinical signs and pathological findings in the GI system and brain, we strongly suggest that the BVDV may represent a gastro-neuropathogen strain. To the best of our knowledge, this is the first outbreak of gastro-neuropathogenic BVDV infection in Iran, which may beacquired postnatally.en
dc.description.statementofresponsibilityBazargani T. T., Hemmatzadeh F., Nadjafi J. and Sadeghi Nasab A.en
dc.publisherShiraz Universityen
dc.subjectBVDV; Gastro-neuropathogen strain; RT-PCR; Immunohistochemistry; Histopathologyen
dc.titleBVDV induced gastro-neuropathy outbreak in a feedlot calves around Tehran (Iran)en
dc.typeJournal articleen
dc.identifier.orcidHemmatzadeh, F. [0000-0002-4572-8869]en
Appears in Collections:Animal and Veterinary Sciences publications

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