Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/6883
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Type: Journal article
Title: The origin and fate of herniated lumbar invertebral disc tissue
Author: Moore, R.
Vernon-Roberts, B.
Fraser, R.
Osti, O.
Schembri, M.
Citation: Spine, 1996; 21(18):2149-2155
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Issue Date: 1996
ISSN: 0362-2436
1528-1159
Statement of
Responsibility: 
Robert J. Moore, Barrie Vernon-Roberts, Robert D. Fraser, Orso L. Osti, Mark Schembri
Abstract: Study Design: In a clinicopathologic study, disc tissue collected from surgery and from cadaveric spines was examined to test an hypothesis about the pathogenesis of herniation. Objectives: To determine the origin and fate of herniated lumbar intervertebral disc tissue. Summary of Background Data: Previous studies have ascribed herniated disc tissue to the nucleus, anulus, or endplate, or combinations of the three. One study describes it as newly synthesized fibrocartilage. Regardless of its origin, peripheral neovascularization of disc fragments has been described and may be related to pain symptoms. Methods: Disc tissue was collected after extrusion and was examined histologically to determine its origin and fate. To test the hypothesis that sequestration results from migration of isolated, degenerate fragments of nucleus pulposus through preexisting tears in the anulus fibrosus, cadaveric lumbar discs were examined in detail. Results: Ninety-eight percent of sequestrations contained some nuclear material indicating that nucleus pulposus is the principal substance extruded from the disc. None contained anulus alone. Although vascular repair was present in 89% of specimens, it did not correlate with several clinical parameters. Conclusions: The autopsy study confirmed the model of nuclear fragmentation, migration, and extrusion along radiating anular clefts. Neovascularization of extruded fragments bore no relationship with duration of sciatic pain symptoms or clinical outcome.
Keywords: disc degeneration; disc herniation; neovascularization; pain
Rights: Copyright: © Lippincott-Raven Publishers
RMID: 0030005780
DOI: 10.1097/00007632-199609150-00018
Appears in Collections:Orthopaedics and Trauma publications

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