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Type: Journal article
Title: OPRM1 A118G genotype fails to predict the effectiveness of naltrexone treatment for alcohol dependence
Author: Coller, J.
Cahill, S.
Edmonds, C.
Farquharson, A.
Longo, M.
Minniti, R.
Sullivan, T.
Somogyi, A.
White, J.
Citation: Pharmacogenetics and Genomics, 2011; 21(12):902-905
Publisher: Lippincott Williams & Wilkins
Issue Date: 2011
ISSN: 1744-6872
Statement of
Janet K. Coller, Sharon Cahill, Carolyn Edmonds, Aaron L. Farquharson, Marie Longo, Rinaldo Minniti, Thomas Sullivan, Andrew A. Somogyi and Jason M. White
Abstract: Given the evidence from retrospective studies indicating that alcohol-dependent patients with homozygous or heterozygous A118G variant of the µ-opioid receptor, OPRM1, gene have significantly better outcomes when treated with naltrexone; this study examined this prospectively in 100 alcohol-dependent participants prescribed naltrexone for 12 weeks and offered six sessions of cognitive-behavioral therapy or intervention. Comparisons were made among OPRM1 genotypic groups on several outcome measures. Naltrexone treatment produced significant decreases in self-reported and objective indicators of alcohol use and craving from baseline (P<0.0001 and 0.017, respectively), particularly during the first 2 months of treatment, with 68% completing the study. However, there was no evidence of a significant association between OPRM1 A118G genotype and treatment success on any of the outcome measures. Therefore, while naltrexone was an effective treatment for alcohol dependence, the OPRM1 A118G genotype was not a predictor of success.
Keywords: alcohol
naltrexone treatment
OPRM1 A118G genotype
Rights: © 2011 Lippincott Williams & Wilkins, Inc.
DOI: 10.1097/FPC.0b013e32834c5445
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