Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/6899
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Type: Journal article
Title: Nutritional effect of including egg yolk in the weaning diet of breast-fed and formula-fed infants: a randomized controlled trial
Author: Makrides, M.
Hawkes, J.
Neuman, M.
Gibson, R.
Citation: American Journal of Clinical Nutrition, 2002; 75(6):1084-1092
Publisher: Amer Soc Clinical Nutrition
Issue Date: 2002
ISSN: 0002-9165
1938-3207
Statement of
Responsibility: 
Maria Makrides, Joanna S Hawkes, Mark A Neumann and Robert A Gibson
Abstract: Background: Egg yolks can be a source of docosahexaenoic acid (DHA) and iron but are often associated with adverse consequences on plasma cholesterol. Objective: Our goal was to investigate the effect of consumption of 4 egg yolks/wk on infant DHA status and hemoglobin, ferritin, and plasma cholesterol concentrations. Secondary outcomes included plasma iron, transferrin, and transferrin saturation. Design: This was a randomized controlled trial comparing no dietary intervention, consumption of 4 regular egg yolks/wk, and consumption of 4 n-3 fatty acid–enriched egg yolks/wk in breast-fed and formula-fed infants from 6 to 12 mo of age. Erythrocyte DHA concentrations, cholesterol, and iron status were assessed at 6 and 12 mo of age. Results: Of the 82 breast-fed infants recruited, 23 of 28 (no intervention), 23 of 27 (regular eggs), and 24 of 27 (n-3 eggs) completed the trial. Of the 79 formula-fed infants enrolled, 23 of 27 (no intervention), 24 of 26 (regular eggs), and 20 of 26 (n-3 eggs) completed the trial. Erythrocyte DHA concentrations were 30–40% higher after the n-3 egg intervention than after treatment with regular eggs or no eggs in both breast-fed and formula-fed infants. Egg treatment had no significant effect on plasma cholesterol, hemoglobin, ferritin, and transferrin but did result in improvements in plasma iron and transferrin saturation compared with no egg treatment. Conclusions: n-3 Fatty acid–enriched eggs may provide a means of increasing dietary DHA during the second 6 mo of life. Egg yolks may also be a useful source of iron during the weaning period and can be safely included in the weaning diet with no perturbations in plasma cholesterol. 2002; 75:1084–92.
Keywords: Weaning diet; infants; randomized controlled trial; docosahexaenoic acid; iron; cholesterol; egg
RMID: 0020022447
DOI: 10.1093/ajcn/75.6.1084
Published version: http://www.ajcn.org/cgi/content/full/75/6/1084
Appears in Collections:Paediatrics publications

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