Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/69194
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Type: Journal article
Title: Silver deposits in cutaneous burn scar tissue is a common phenomenon following application of a silver dressing
Author: Wang, X.
Chang, H.
Francis, R.
Olszowy, H.
Liu, P.
Kempf, M.
Cuttle, L.
Kravchuk, O.
Phillips, G.
Kimble, R.
Citation: Journal of Cutaneous Pathology, 2009; 36(7):788-792
Publisher: Munksgaard Int Publ Ltd
Issue Date: 2009
ISSN: 0303-6987
1600-0560
Statement of
Responsibility: 
Xue-Qing Wang, Hong-En Chang, Rod Francis, Henry Olszowy, Pei-Yun Liu, Margit Kempf, Leila Cuttle, Olena Kravchuk, Gael E. Phillips and Roy M. Kimble
Abstract: Background: Silver dressings have been widely and successfully used to prevent cutaneous wounds, including burns, chronic ulcers, dermatitis and other cutaneous conditions, from infection. However, in a few cases, skin discolouration or argyria-like appearances have been reported. This study investigated the level of silver in scar tissue post-burn injury following application of Acticoat™, a silver dressing. Methods: A porcine deep dermal partial thickness burn model was used. Burn wounds were treated with this silver dressing until completion of re-epithelialization, and silver levels were measured in a total of 160 scars and normal tissues. Results: The mean level of silver in scar tissue covered with silver dressings was 136 μg/g, while the silver level in normal skin was less than 0.747 μg/g. A number of wounds had a slate-grey appearance, and dissection of the scars revealed brown-black pigment mostly in the middle and deep dermis within the scar. The level of silver and the severity of the slate-grey discolouration were correlated with the length of time of the silver dressing application. Conclusions: These results show that silver deposition in cutaneous scar tissue is a common phenomenon, and higher levels of silver deposits and severe skin discolouration are correlated with an increase in the duration of this silver dressing application.
Keywords: Cicatrix; Dermis; Animals; Swine; Humans; Burns; Silver; Polyethylenes; Polyesters; Pigmentation; Female
Rights: Copyright 2009 John Wiley & Sons A/S.
RMID: 0020114455
DOI: 10.1111/j.1600-0560.2008.01141.x
Appears in Collections:Agriculture, Food and Wine publications

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