Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/69223
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dc.contributor.authorCirillo, J.en
dc.contributor.authorTodd, G.en
dc.contributor.authorSemmler, J.en
dc.date.issued2011en
dc.identifier.citationEuropean Journal of Neuroscience, 2011; 34(11):1847-1856en
dc.identifier.issn0953-816Xen
dc.identifier.issn1460-9568en
dc.identifier.urihttp://hdl.handle.net/2440/69223-
dc.description.abstractPrevious studies with transcranial magnetic stimulation (TMS) have shown that advancing age may influence plasticity induction in human motor cortex (M1), but these changes have been assessed with TMS-induced paradigms or simple motor tasks. The aim of this study was to examine changes in corticospinal excitability and intracortical inhibition as markers of corticomotor plasticity following complex motor training in young and old adults. Electromyographic recordings were obtained from the right first dorsal interosseous (FDI) muscle of 16 young (20–35 years) and 16 older (aged 60–75 years) adults before and after motor skill training. Motor training consisted of three 6-minute blocks of a complex visuomotor task that required matching the metacarpophalangeal (MCP) joint angle of the index finger using abduction–adduction movements. Single- and paired-pulse TMS over the left M1 was used to assess changes in right FDI motor-evoked potentials (MEPs) and short-interval intracortical inhibition (SICI) before and after each training block. Visuomotor tracking performance was diminished in old compared with young adults throughout training. However, improvement in tracking error was similar for young and old adults (7–24% increase in each training block). For young and old adults, motor training increased FDI MEP amplitude (≥ 20%) and reduced the magnitude of SICI (≥ 19%) after each visuomotor training block, reflecting use-dependent plasticity. However, no difference in corticomotor plasticity (change in MEP or SICI) was observed between young and old adults. Further studies are needed to identify the experimental or behavioral factors that might contribute to the maintenance of corticomotor plasticity in older adults.en
dc.description.statementofresponsibilityJohn Cirillo, Gabrielle Todd and John G. Semmleren
dc.language.isoenen
dc.publisherBlackwell Science Ltden
dc.rights© 2011 The Authors. European Journal of Neuroscience © 2011 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.en
dc.subjectaging; motor cortex; motor skill; transcranial magnetic stimulationen
dc.titleCorticomotor excitability and plasticity following complex visuomotor training in young and old adultsen
dc.typeJournal articleen
dc.identifier.rmid0020115179en
dc.identifier.doi10.1111/j.1460-9568.2011.07870.xen
dc.identifier.pubid26584-
pubs.library.collectionPsychology publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidSemmler, J. [0000-0003-0260-8047]en
Appears in Collections:Psychology publications

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