Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/6928
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Type: Journal article
Title: PEHO and PEHO-like syndromes: Report of five Australian cases
Author: Field, M.
Grattan-Smith, P.
Piper, S.
Thompson, E.
Haan, E.
Edwards, M.
James, S.
Wilkinson, I.
Ades, L.
Citation: American Journal of Medical Genetics. Part A, 2003; 122A(1):6-12
Publisher: Wiley-Liss
Issue Date: 2003
ISSN: 1552-4825
1552-4833
Statement of
Responsibility: 
M.J. Field, P. Grattan-Smith, S.M. Piper, E.M. Thompson, E.A. Haan, M. Edwards, S. James, I. Wilkinson, and L.C. Adès
Abstract: PEHO syndrome is a rare progressive infantile encephalopathy with onset within the first few months of life. Few patients fulfilling the diagnostic criteria for PEHO syndrome have been reported outside Finland. Affected infants have facial dysmorphism and suffer from severe hypotonia, profound mental retardation, convulsions (often with a hypsarrhythmic EEG pattern), transient or persistent peripheral oedema, and optic atrophy. Cerebellar and brainstem atrophy are usually present on neuroimaging. A PEHO-like syndrome has been described, in which the affected individuals have neither optic atrophy nor the typical neuroradiological findings. We report five Australian patients, the first with classical features of PEHO syndrome, and four who have a PEHO-like disorder. We compare their features with other published cases. We suggest that PEHO or a PEHO-like syndrome may affect more patients than are currently identified, based on the original diagnostic criteria for this disorder.
Keywords: hypsarrhythmia; progressive encephalopathy; oedema; optic atrophy
Rights: © 2003 Wiley-Liss, Inc.
RMID: 0020031174
DOI: 10.1002/ajmg.a.20216
Appears in Collections:Paediatrics publications

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