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Type: Journal article
Title: Mechanisms of resistance to BCR-ABL kinase inhibitors
Author: Diamond, J.
Vaz de Melo, J.
Citation: Leukemia and Lymphoma, 2011; 52(SUPPL. 1):12-22
Publisher: Taylor & Francis Ltd
Issue Date: 2011
ISSN: 1042-8194
Statement of
Joana M. Diamond & Junia V. Melo
Abstract: Since the introduction of imatinib mesylate (IM) for the treatment of chronic myeloid leukemia (CML), impressive clinical responses have been observed in the majority of patients in chronic phase. However, not all patients experience an optimal response to IM or even to the more potent, second-generation tyrosine kinase inhibitors (TKIs). Furthermore, responses are not sustained in a number of patients, and it is yet unclear whether the inhibitors can be safely discontinued in patients who achieve long-term remission. The emergence of resistance to TKIs has become a significant problem that has led to extensive studies on the causal mechanisms. This review describes our current state of knowledge on why and how CML cells can develop resistance to TKIs.
Keywords: TKI
Rights: © 2011 Informa UK, Ltd.
DOI: 10.3109/10428194.2010.546920
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Appears in Collections:Aurora harvest
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