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Type: Journal article
Title: Is there a relationship between Wolfram syndrome carrier status and suicide?
Author: Crawford, J.
Zielinski, M.
Fisher, L.
Sutherland, G.
Goldney, R.
Citation: American Journal of Medical Genetics. Part A, 2002; 114(3):343-346
Publisher: Wiley-Liss
Issue Date: 2002
ISSN: 1552-4825
Statement of
Joanna Crawford, Marta A. Zielinski, Laura J. Fisher, Grant R. Sutherland, Robert D. Goldney
Abstract: Wolfram syndrome (WFS) is a rare, autosomal recessive neurodegenerative disorder. An increased risk of psychiatric disorders and suicide has been reported for heterozygote carriers. In this study we investigated whether mutations in the WFS gene are associated with suicide in the general population. The gene for WFS (WFS1) has recently been mapped to chromosome 4p16.1, and its genomic structure has been characterized. We screened the entire WFS1 ORF in a panel of 100 completed suicides, 60 blood donors not known to have psychiatric illness, and 100 donors with a negative history of depression or suicidal behavior. We did not find evidence of an increased incidence of WFS carriers in the suicide panel and concluded that WFS1 carrier status is not a significant contributor to suicide in the general population. Screening of this highly polymorphic gene resulted in the detection of 33 variants, 13 of which cause amino acid changes. Seven of these changes have not been previously reported and six were unique to our suicide panel.
Keywords: Humans; Wolfram Syndrome; Membrane Proteins; DNA; DNA Mutational Analysis; Suicide; Gene Frequency; Heterozygote; Mutation, Missense; Point Mutation; Polymorphism, Single-Stranded Conformational; Polymorphism, Single Nucleotide; Alleles; Adult; Middle Aged
Description: Published in American Journal of Medical Genetics, 2002; 114 (3):343-346 at
RMID: 0020020547
DOI: 10.1002/ajmg.10256
Appears in Collections:Paediatrics publications

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