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|Title:||Unbalanced t(4;11)(q32-q23) in a 34-year-old man with manifestations of distal monosomy 11q and trisomy 4q syndromes|
|Citation:||American Journal of Medical Genetics, 1997; 70(4):357-360|
|Byatt, S A ; Baker, E ; Richards, R I ; Roberts, C; Smith, A|
|Abstract:||We present a 34-year-old man with an unbalanced translocation between the long arms of chromosome 4 and chromosome 11. He had manifestations of monosomy 11(q23)--minor facial anomalies, abnormal head shape, cryptorchidism; trisomy 4(q32)--hirsutism, renal disease; and manifestations attributable to both imbalances--heart disease, musculoskeletal anomalies, and mental retardation. FISH studies showed that the chromosome 11q23.3 translocation breakpoint was distal to the rare folate sensitive fragile site (FRA11B). The patient is the oldest reported with both imbalance of 4q+ and 11q-.|
|Keywords:||Head; Face; Chromosomes, Human, Pair 4; Chromosomes, Human, Pair 11; Humans; Musculoskeletal Abnormalities; Monosomy; Trisomy; Translocation, Genetic; In Situ Hybridization, Fluorescence; Phenotype; Adult; Female; Male; Intellectual Disability|
|Appears in Collections:||Paediatrics publications|
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