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Type: Journal article
Title: Warfarin and acetaminophen interaction: a summary of the evidence and biologic plausibility
Author: Lopes, R.
Horowitz, J.
Garcia, D.
Crowther, M.
Hylek, E.
Citation: Blood, 2011; 118(24):6269-6273
Publisher: Amer Soc Hematology
Issue Date: 2011
ISSN: 0006-4971
Statement of
Renato D. Lopes, John D. Horowitz, David A. Garcia, Mark A. Crowther and Elaine M. Hylek
Abstract: Ms TS is a 66-year-old woman who receives warfarin for prevention of systemic embolization in the setting of hypertension, diabetes, and atrial fibrillation. She had a transient ischemic attack about 4 years ago when she was receiving aspirin. Her INR control was excellent; however, over the past few months it has become erratic, and her average dose required to maintain an INR of 2.0 to 3.0 appears to have decreased. She has had back pain over this same period and has been taking acetaminophen at doses at large as 650 mg four times daily, with her dose varying based on her symptoms. You recall a potential interaction and wonder if (1) her acetaminophen use is contributing to her loss of INR control, and (2) does this interaction place her at increased risk of warfarin-related complications?
Keywords: Humans
Back Pain
Atrial Fibrillation
Diabetes Complications
Vitamin K
Analgesics, Non-Narcotic
Drug Monitoring
International Normalized Ratio
Drug Interactions
Rights: © 2011 by The American Society of Hematology
DOI: 10.1182/blood-2011-08-335612
Appears in Collections:Agriculture, Food and Wine publications
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