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https://hdl.handle.net/2440/69464
Type: | Thesis |
Title: | The role of substance P in cerebral edema associated with rat and human infarction and contusion |
Author: | Hassan, Islam Khamis Ahmed Mohamed |
Issue Date: | 2006 |
School/Discipline: | Dept. of Pathology |
Abstract: | An important influence on the severity of both traumatic brain injury (TBI) and stroke is cerebral edema, but its mechanism is poorly understood. Recent evidence suggests that substance P (SP) plays a role in this edema and that injured SP-containing perivascular nerve fibres are involved. A study which examined tissue obtained from rat models and human post mortem infarct and contusion tissue, demonstrated that in all the examined tissue, perivascular SP-IR was present in astrocytic processes rather than in nerve fibres. This implies that perivascular astrocytic processes might be more important than perivascular nerve fibres in any effect that SP may have on the blood brain barrier in the settings of infarction and contusion. |
Dissertation Note: | Thesis (M.Med.Sc.) -- University of Adelaide, Dept. of Pathology, 2006 |
Keywords: | substance P; cerebral edema; rats |
Provenance: | This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exception. If you are the author of this thesis and do not wish it to be made publicly available or If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legals |
Appears in Collections: | Research Theses |
Files in This Item:
File | Description | Size | Format | |
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01front.pdf | 43.23 kB | Adobe PDF | View/Open | |
02whole.pdf | 7.64 MB | Adobe PDF | View/Open |
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