Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/6959
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Type: Journal article
Title: Use of high-performance liquid chromatography to study the pharmacokinetics of colistin sulfate in rats following intravenous administration
Author: Li, J.
Milne, R.
Nation, R.
Turnidge, J.
Smeaton, T.
Coulthard, K.
Citation: Antimicrobial Agents and Chemotherapy, 2003; 47(5):1766-1770
Publisher: Amer Soc Microbiology
Issue Date: 2003
ISSN: 0066-4804
1098-6596
Abstract: The pharmacokinetics of colistin was investigated using specific high-performance liquid chromatography (HPLC) to measure the concentrations of colistin and colistin A and B in plasma and urine in five rats after administration of an intravenous bolus of 1 mg of colistin sulfate/kg of body weight. There were differences in the pharmacokinetic behaviors of unbound colistin A and B. This is the first report of the use of HPLC to study the pharmacokinetics of colistin and its two major components.
Keywords: Animals
Rats
Rats, Sprague-Dawley
Colistin
Anti-Bacterial Agents
Metabolic Clearance Rate
Chromatography, High Pressure Liquid
Injections, Intravenous
Protein Binding
Male
DOI: 10.1128/AAC.47.5.1766-1770.2003
Appears in Collections:Aurora harvest 5
Paediatrics publications

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