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Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/6959
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dc.contributor.authorLi, J.-
dc.contributor.authorMilne, R.-
dc.contributor.authorNation, R.-
dc.contributor.authorTurnidge, J.-
dc.contributor.authorSmeaton, T.-
dc.contributor.authorCoulthard, K.-
dc.date.issued2003-
dc.identifier.citationAntimicrobial Agents and Chemotherapy, 2003; 47(5):1766-1770-
dc.identifier.issn0066-4804-
dc.identifier.issn1098-6596-
dc.identifier.urihttp://hdl.handle.net/2440/6959-
dc.description.abstractThe pharmacokinetics of colistin was investigated using specific high-performance liquid chromatography (HPLC) to measure the concentrations of colistin and colistin A and B in plasma and urine in five rats after administration of an intravenous bolus of 1 mg of colistin sulfate/kg of body weight. There were differences in the pharmacokinetic behaviors of unbound colistin A and B. This is the first report of the use of HPLC to study the pharmacokinetics of colistin and its two major components.-
dc.language.isoen-
dc.publisherAmer Soc Microbiology-
dc.source.urihttp://dx.doi.org/10.1128/aac.47.5.1766-1770.2003-
dc.subjectAnimals-
dc.subjectRats-
dc.subjectRats, Sprague-Dawley-
dc.subjectColistin-
dc.subjectAnti-Bacterial Agents-
dc.subjectMetabolic Clearance Rate-
dc.subjectChromatography, High Pressure Liquid-
dc.subjectInjections, Intravenous-
dc.subjectProtein Binding-
dc.subjectMale-
dc.titleUse of high-performance liquid chromatography to study the pharmacokinetics of colistin sulfate in rats following intravenous administration-
dc.typeJournal article-
dc.identifier.doi10.1128/AAC.47.5.1766-1770.2003-
pubs.publication-statusPublished-
dc.identifier.orcidTurnidge, J. [0000-0003-4240-5578]-
Appears in Collections:Aurora harvest 5
Paediatrics publications

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