Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/69643
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Type: Journal article
Title: Uptake and distribution of a platinum(II)-carborane complex within a tumour cell using synchrotron XRF imaging
Author: Crossley, E.
Aitken, J.
Vogt, S.
Harris, H.
Rendina, L.
Citation: Australian Journal of Chemistry, 2011; 64(3):253-257
Publisher: C S I R O Publishing
Issue Date: 2011
ISSN: 0004-9425
1445-0038
Statement of
Responsibility: 
Ellen L. Crossley, Jade B. Aitken, Stefan Vogt, Hugh H. Harris and Louis M. Rendina
Abstract: Treatment of A549 human lung carcinoma cells with a DNA metallointercalator complex containing a PtII-terpy (terpy = 2,2′:6′,2′′-terpyridine) unit linked to a functionalized closo-carborane cage results in the uptake of the complex within the cells, as determined by synchrotron X-ray fluorescence (XRF) imaging. Although a significant cellular uptake of Pt existed, there was no significant accumulation of the element within the cell nuclei. Other statistically significant changes from the XRF data included an increase in Cl, K, and Cu and a decrease in Fe within the treated cells.
Rights: Copyright CSIRO 2011
RMID: 0020111826
DOI: 10.1071/CH10453
Grant ID: http://purl.org/au-research/grants/arc/DP0557118
http://purl.org/au-research/grants/arc/DP0664706
Appears in Collections:Chemistry publications
Environment Institute publications

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