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Type: Journal article
Title: Vitamin D metabolism within bone cells: Effects on bone structure and strength
Author: Anderson, P.
Atkins, G.
Turner, A.
Kogawa, M.
Findlay, D.
Morris, H.
Citation: Molecular and Cellular Endocrinology, 2011; 347(1-2 Sp Is):42-47
Publisher: Elsevier Sci Ireland Ltd
Issue Date: 2011
ISSN: 0303-7207
Statement of
Paul H. Anderson, Gerald J. Atkins, Andrew G. Turner, Masakazu Kogawa, David M. Findlay, Howard A. Morris
Abstract: The endocrine activity of 1,25-dihydroxyvitamin D (1,25(OH)(2)D(3)) contributes to maintaining plasma calcium and phosphate homeostasis through actions on the intestine, kidney and bone. A significant body of evidence has been published over the last 10 years indicating that all major bone cells have the capacity to metabolise 25-hydroxyvitamin D (25(OH)D(3)) to 1,25(OH)(2)D(3), which in turn exerts autocrine/paracrine actions to regulate bone cell proliferation and maturation as well as bone mineralisation and resorption. In vivo and in vitro studies indicate that these autocrine/paracrine activities of 1,25(OH)(2)D(3) in bone tissue contribute to maintaining bone mineral homeostasis and enhancing skeletal health.
Keywords: Vitamin D metabolism
Bone architecture
Bone cell metabolism
Rights: Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
DOI: 10.1016/j.mce.2011.05.024
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