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|Title:||Vitamin D metabolism within bone cells: Effects on bone structure and strength|
|Citation:||Molecular and Cellular Endocrinology, 2011; 347(1-2 Sp Is):42-47|
|Publisher:||Elsevier Sci Ireland Ltd|
|Paul H. Anderson, Gerald J. Atkins, Andrew G. Turner, Masakazu Kogawa, David M. Findlay, Howard A. Morris|
|Abstract:||The endocrine activity of 1,25-dihydroxyvitamin D (1,25(OH)(2)D(3)) contributes to maintaining plasma calcium and phosphate homeostasis through actions on the intestine, kidney and bone. A significant body of evidence has been published over the last 10 years indicating that all major bone cells have the capacity to metabolise 25-hydroxyvitamin D (25(OH)D(3)) to 1,25(OH)(2)D(3), which in turn exerts autocrine/paracrine actions to regulate bone cell proliferation and maturation as well as bone mineralisation and resorption. In vivo and in vitro studies indicate that these autocrine/paracrine activities of 1,25(OH)(2)D(3) in bone tissue contribute to maintaining bone mineral homeostasis and enhancing skeletal health.|
|Keywords:||Vitamin D metabolism; Osteoblast; Bone architecture; Osteoclast; Bone cell metabolism|
|Rights:||Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.|
|Appears in Collections:||Orthopaedics and Trauma publications|
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