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https://hdl.handle.net/2440/69699
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Type: | Journal article |
Title: | Vitamin D metabolism within bone cells: Effects on bone structure and strength |
Author: | Anderson, P. Atkins, G. Turner, A. Kogawa, M. Findlay, D. Morris, H. |
Citation: | Molecular and Cellular Endocrinology, 2011; 347(1-2 Sp Is):42-47 |
Publisher: | Elsevier Sci Ireland Ltd |
Issue Date: | 2011 |
ISSN: | 0303-7207 1872-8057 |
Statement of Responsibility: | Paul H. Anderson, Gerald J. Atkins, Andrew G. Turner, Masakazu Kogawa, David M. Findlay, Howard A. Morris |
Abstract: | The endocrine activity of 1,25-dihydroxyvitamin D (1,25(OH)(2)D(3)) contributes to maintaining plasma calcium and phosphate homeostasis through actions on the intestine, kidney and bone. A significant body of evidence has been published over the last 10 years indicating that all major bone cells have the capacity to metabolise 25-hydroxyvitamin D (25(OH)D(3)) to 1,25(OH)(2)D(3), which in turn exerts autocrine/paracrine actions to regulate bone cell proliferation and maturation as well as bone mineralisation and resorption. In vivo and in vitro studies indicate that these autocrine/paracrine activities of 1,25(OH)(2)D(3) in bone tissue contribute to maintaining bone mineral homeostasis and enhancing skeletal health. |
Keywords: | Vitamin D metabolism Osteoblast Bone architecture Osteoclast Bone cell metabolism |
Rights: | Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
DOI: | 10.1016/j.mce.2011.05.024 |
Published version: | http://dx.doi.org/10.1016/j.mce.2011.05.024 |
Appears in Collections: | Aurora harvest Orthopaedics and Trauma publications |
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