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https://hdl.handle.net/2440/69699
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dc.contributor.author | Anderson, P. | - |
dc.contributor.author | Atkins, G. | - |
dc.contributor.author | Turner, A. | - |
dc.contributor.author | Kogawa, M. | - |
dc.contributor.author | Findlay, D. | - |
dc.contributor.author | Morris, H. | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Molecular and Cellular Endocrinology, 2011; 347(1-2 Sp Is):42-47 | - |
dc.identifier.issn | 0303-7207 | - |
dc.identifier.issn | 1872-8057 | - |
dc.identifier.uri | http://hdl.handle.net/2440/69699 | - |
dc.description.abstract | The endocrine activity of 1,25-dihydroxyvitamin D (1,25(OH)(2)D(3)) contributes to maintaining plasma calcium and phosphate homeostasis through actions on the intestine, kidney and bone. A significant body of evidence has been published over the last 10 years indicating that all major bone cells have the capacity to metabolise 25-hydroxyvitamin D (25(OH)D(3)) to 1,25(OH)(2)D(3), which in turn exerts autocrine/paracrine actions to regulate bone cell proliferation and maturation as well as bone mineralisation and resorption. In vivo and in vitro studies indicate that these autocrine/paracrine activities of 1,25(OH)(2)D(3) in bone tissue contribute to maintaining bone mineral homeostasis and enhancing skeletal health. | - |
dc.description.statementofresponsibility | Paul H. Anderson, Gerald J. Atkins, Andrew G. Turner, Masakazu Kogawa, David M. Findlay, Howard A. Morris | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Sci Ireland Ltd | - |
dc.rights | Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.mce.2011.05.024 | - |
dc.subject | Vitamin D metabolism | - |
dc.subject | Osteoblast | - |
dc.subject | Bone architecture | - |
dc.subject | Osteoclast | - |
dc.subject | Bone cell metabolism | - |
dc.title | Vitamin D metabolism within bone cells: Effects on bone structure and strength | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.mce.2011.05.024 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Anderson, P. [0000-0002-8685-3252] | - |
dc.identifier.orcid | Atkins, G. [0000-0002-3123-9861] | - |
dc.identifier.orcid | Morris, H. [0000-0002-2745-3750] | - |
Appears in Collections: | Aurora harvest Orthopaedics and Trauma publications |
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