Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Full metadata record
DC FieldValueLanguage
dc.contributor.authorWang, Q.-
dc.contributor.authorBailey, C.-
dc.contributor.authorNg, C.-
dc.contributor.authorTiffen, J.-
dc.contributor.authorThoeng, A.-
dc.contributor.authorMinhas, V.-
dc.contributor.authorLehman, M.-
dc.contributor.authorHendy, S.-
dc.contributor.authorBuchanan, G.-
dc.contributor.authorNelson, C.-
dc.contributor.authorRasko, J.-
dc.identifier.citationCancer Research, 2011; 71(24):7525-7536-
dc.description.abstractL-Type amino acid transporters such as LAT1 and LAT3 mediate the uptake of essential amino acids. Here, we report that prostate cancer cells coordinate the expression of LAT1 and LAT3 to maintain sufficient levels of leucine needed for mTORC1 signaling and cell growth. Inhibiting LAT function was sufficient to decrease cell growth and mTORC1 signaling in prostate cancer cells. These cells maintained levels of amino acid influx through androgen receptor-mediated regulation of LAT3 expression and ATF4 regulation of LAT1 expression after amino acid deprivation. These responses remained intact in primary prostate cancer, as indicated by high levels of LAT3 in primary disease, and by increased levels of LAT1 after hormone ablation and in metastatic lesions. Taken together, our results show how prostate cancer cells respond to demands for increased essential amino acids by coordinately activating amino acid transporter pathways vital for tumor outgrowth.-
dc.description.statementofresponsibilityQian Wang, Charles G. Bailey, Cynthia Ng, Jessamy Tiffen, Annora Thoeng, Vineet Minhas, Melanie L. Lehman, Stephen C. Hendy, Grant Buchanan, Colleen C. Nelson, John E.J. Rasko and Jeff Holst-
dc.publisherAmer Assoc Cancer Research-
dc.rights©2011 AACR-
dc.subjectCell Line, Tumor-
dc.subjectMice, Nude-
dc.subjectProstatic Neoplasms-
dc.subjectDisease Progression-
dc.subjectAmino Acids-
dc.subjectAmino Acids, Cyclic-
dc.subjectAmino Acid Transport Systems, Basic-
dc.subjectLarge Neutral Amino Acid-Transporter 1-
dc.subjectReceptors, Androgen-
dc.subjectBlotting, Western-
dc.subjectTransplantation, Heterologous-
dc.subjectReverse Transcriptase Polymerase Chain Reaction-
dc.subjectNeoplasm Transplantation-
dc.subjectSignal Transduction-
dc.subjectCell Proliferation-
dc.subjectGene Expression Regulation, Neoplastic-
dc.subjectRNA Interference-
dc.subjectBiological Transport-
dc.subjectActivating Transcription Factor 4-
dc.subjectHEK293 Cells-
dc.subjectTOR Serine-Threonine Kinases-
dc.titleAndrogen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport during prostate cancer progression-
dc.typeJournal article-
Appears in Collections:Aurora harvest 5
Medicine publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.