Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/69807
Citations
Scopus Web of Science® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorWong, C.en
dc.contributor.authorLim, H.en
dc.contributor.authorSchultz, C.en
dc.contributor.authorSanders, P.en
dc.contributor.authorWorthley, M.en
dc.contributor.authorWilloughby, S.en
dc.date.issued2012en
dc.identifier.citationClinical and Experimental Pharmacology and Physiology, 2012; 39(2):141-144en
dc.identifier.issn0305-1870en
dc.identifier.issn1440-1681en
dc.identifier.urihttp://hdl.handle.net/2440/69807-
dc.description.abstract1. Endothelial function is an independent predictor of adverse cardiovascular outcomes. The evaluation of endothelial function via changes in vessel diameter or blood flow may be inaccurate during atrial fibrillation (AF) because of non-uniform stroke volumes. 2. Using peripheral arterial tonometry, 50 patients with AF (25 in AF, 25 in sinus rhythm) had digital pulse amplitudes assessed at baseline and during reactive hyperaemia. Hyperaemic responses were compared over varying measurement durations (5, 10 and 15 beats; 30 s; and 1–10 min) to determine optimal measurement duration. 3. Endothelial responses were significantly decreased (indicating endothelial dysfunction) in patients in AF compared with patients in sinus rhythm (1.48 ± 0.60 vs 2.05 ± 1.13, respectively; P = 0.03). 4. Beat-to-beat pulse amplitude was highly variable during AF; although coefficients of variation (CV) for short measurement durations were large, these decreased with longer measurement durations. Bland–Altman plots revealed that limits of agreement for short measurement durations were poor. Limits of agreement became consistently narrower when measurement durations of at least 1 min were used. In contrast, limits of agreement and CV for short measurement durations during sinus rhythm were significantly narrower and smaller, respectively, than during AF over similar measurement durations. 5. Pulse amplitudes are highly variable owing to the non-uniform stroke volumes in AF. Our results suggest that methods of determining endothelial function via vessel diameters or blood flow during reactive hyperaemia should use measurement durations of at least 1 min to ensure accurate and reproducible results.en
dc.description.statementofresponsibilityChristopher X Wong, Han S Lim, Carlee D Schultz, Prashanthan Sanders, Matthew I Worthley and Scott R Willoughbyen
dc.language.isoenen
dc.publisherBlackwell Publishing Asiaen
dc.rightsCopyright 2011 The Authors. Clinical and Experimental Pharmacology and Physiology Copyright 2011 Blackwell Publishing Asia Pty Ltden
dc.subjectatrial fibrillation; endothelial function; endothelium; vascular functionen
dc.titleAssessment of endothelial function in atrial fibrillation: utility of peripheral arterial tonometryen
dc.typeJournal articleen
dc.identifier.rmid0020116226en
dc.identifier.doi10.1111/j.1440-1681.2011.05647.xen
dc.identifier.pubid26060-
pubs.library.collectionMedicine publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidWong, C. [0000-0002-1913-6675]en
dc.identifier.orcidSanders, P. [0000-0003-3803-8429]en
Appears in Collections:Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.