Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/69878
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Type: Journal article
Title: Auditory evoked potentials remain abnormal after CPAP treatment in patients with severe obstructive sleep apnoea
Author: Vakulin, A.
Catcheside, P.
Baulk, S.
Antic, N.
van den Heuvel, C.
Banks, S.
McEvoy, R.
Citation: Clinical Neurophysiology, 2012; 123(2):310-317
Publisher: Elsevier Sci Ireland Ltd
Issue Date: 2012
ISSN: 1388-2457
1872-8952
Statement of
Responsibility: 
Andrew Vakulin, Peter G. Catcheside, Stuart D. Baulk, Nick A. Antic, Cameron J. van den Heuvel, Siobhan Banks and R. Doug McEvoy
Abstract: OBJECTIVE: To assess the effects of 3 months of optimal CPAP treatment on auditory event related potentials (AERP) in patients with severe obstructive sleep apnoea (OSA) compared with healthy controls. METHODS: Auditory odd-ball related N1, P2, N2 and P3 AERP components were assessed in 9 severe OSA subjects and 9 healthy controls at baseline evaluation and at ∼3 months follow-up in both groups, with OSA subjects treated with continuous positive air-way pressure (CPAP) during this period. RESULTS: Severe OSA subjects showed significantly delayed, P2, N2 and P3 latencies, and significantly different P2 and P3 amplitudes compared to controls at baseline (group effect, all p<0.05). At follow-up evaluation P3 latency shortened in treated OSA patients but remained prolonged compared to controls (group by treatment interaction, p<0.05) despite high CPAP compliance (6h/night). The earlier AERP (P2 and N2) components did not change in either controls or OSA patients at follow-up and remained different in patients versus controls. CONCLUSIONS: This study demonstrates that in severe OSA patients AERP responses show minimal or no improvement and remain abnormal following 3 months of optimal CPAP treatment. SIGNIFICANCE: Persistent cortical sensory processing abnormalities despite treatment in severe OSA may have implications for daytime neurobehavioral performance and safety in OSA patients. AERP responses may help identify residual performance deficits and risks.
Keywords: Obstructive sleep apnoea; ERP; CPAP
Rights: Copyright 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
RMID: 0020115983
DOI: 10.1016/j.clinph.2011.07.004
Description (link): http://www.elsevier.com/wps/find/journaldescription.cws_home/601528/description#description
Appears in Collections:Medical Sciences publications

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