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Type: Journal article
Title: Reticulin fibres anchor leukaemic blasts in the marrow of patients with acute lymphoblastic leukaemia
Author: Nath, S.
Nicholson, I.
Tapp, H.
Zola, H.
Zannettino, A.
Revesz, T.
Citation: Medical Hypotheses, 2011; 77(3):333-335
Publisher: Churchill Livingstone
Issue Date: 2011
ISSN: 0306-9877
Statement of
Shriram V. Nath, Ian Nicholson, Heather Tapp, Heddy Zola, Andrew C.W. Zannettino and Tamas Revesz
Abstract: Reticulin fibrosis has been recognized in childhood ALL at diagnosis as part of the altered stromal structure in the bone marrow (BM). Increased fibre density is correlated with a higher concentration of leukaemia cells in the BM and lower numbers of blasts in peripheral blood. We hypothesize that these fibres anchor the leukaemia cells within the BM in close proximity to BM stromal cells (BMSC). The BMSC are a rich source of growth factors and cytokines which enhance leukaemia cell growth and provide protection against chemotherapy. Mobilizing the cells by breaking the 'anchoring ropes' could lead to greater exposure to apoptotic signals.
Keywords: Bone Marrow Cells; Stromal Cells; Humans; Fibrosis; Reticulin; Intercellular Signaling Peptides and Proteins; Cytokines; Lymphocyte Count; Precursor Cell Lymphoblastic Leukemia-Lymphoma
Rights: Crown Copyright 2011 Published by Elsevier Ltd. All rights reserved.
RMID: 0020112814
DOI: 10.1016/j.mehy.2011.05.007
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Appears in Collections:Paediatrics publications

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