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https://hdl.handle.net/2440/70078
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dc.contributor.author | Hodge, G. | - |
dc.contributor.author | Scott, J. | - |
dc.contributor.author | Osborn, M. | - |
dc.contributor.author | To, L. | - |
dc.contributor.author | Zola, H. | - |
dc.contributor.author | Hodge, S. | - |
dc.contributor.author | Revesz, T. | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Cytokine, 2011; 53(3):286-288 | - |
dc.identifier.issn | 1096-0023 | - |
dc.identifier.issn | 1043-4666 | - |
dc.identifier.uri | http://hdl.handle.net/2440/70078 | - |
dc.description.abstract | <h4>Background</h4>Paediatric oncology patients with febrile neutropenia are usually hospitalised and treated with empirical broad-spectrum antibiotic therapy to counter the risk of infection. However, there is currently no method available to rapidly identify bacteremia in these patients. T-helper-type-1 (Th1) cytokines are required for effective immune response to many pathogenic organisms and T regulatory cells are known suppressors of Th1 cells. We hypothesized that characterization of reduced intracellular Th1 cytokines and increased T regulatory cells (Tregs) may prove useful in identifying infection in childhood oncology patients with febrile neutropenia.<h4>Methods</h4>Intracellular Th 1 cytokines and Tregs were enumerated in peripheral blood from a group of childhood oncology patients with febrile neutropenia using multiparameter flow cytometry.<h4>Results</h4>There was a significant increase in the percentage of CD25(+) CD127(-) CD8(-) CD3(+) Tregs and a significant decrease in Th1 intracellular cytokines IFNγ, IL-2 and TNFα in the blood of culture positive patients compared with culture negative patients.<h4>Conclusions</h4>Enumeration of Tregs and intracellular Th1 cytokines may provide a sensitive, specific test for determining infection in childhood oncology patients before blood culture results become available. | - |
dc.description.statementofresponsibility | G. Hodge, J. Scott, M. Osborn, L.B. To, H. Zola, S. Hodge, T. Revesz | - |
dc.language.iso | en | - |
dc.publisher | Academic Press | - |
dc.rights | Crown copyright © 2010 Published by Elsevier Ltd. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.cyto.2010.11.009 | - |
dc.subject | Febrile neutropenia | - |
dc.subject | Infection | - |
dc.subject | T regulatory cells | - |
dc.subject | Th1 cytokines | - |
dc.title | Increased T regulatory cells and decreased Th1 pro-inflammatory cytokines correlate with culture-positive infection in febrile neutropenia childhood oncology patients | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.cyto.2010.11.009 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Osborn, M. [0000-0002-1288-9930] | - |
dc.identifier.orcid | Hodge, S. [0000-0002-3602-9927] [0000-0002-9401-298X] | - |
dc.identifier.orcid | Revesz, T. [0000-0003-2501-0259] | - |
Appears in Collections: | Aurora harvest Paediatrics publications |
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