Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/70336
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Type: Journal article
Title: The effects of lactoferrin on the intestinal environment of broiler chickens
Author: Geier, M.
Torok, V.
Guo, P.
Allison, G.
Boulianne, M.
Janardhana, V.
Bean, A.
Hughes, R.
Citation: British Poultry Science, 2011; 52(5):564-572
Publisher: Carfax Publishing
Issue Date: 2011
ISSN: 0007-1668
1466-1799
Statement of
Responsibility: 
M.S. Geier, V.A. Torok, P. Guo, G.E. Allison, M. Boulianne, V. Janardhana, A.G.D. Bean and R.J. Hughes
Abstract: 1. The influence of in-feed lactoferrin (Lf) on bird production, intestinal microbiota,mucosal immune system and gut microarchitecture was assessed in male Cobb 500 broiler chickens. 2. Birds were given one of four diets from day of hatch: Control (basal diet with no additives), ZnB (basal dietþ50 mg/kg zinc bacitracin), Lf 250 mg/kg (basal dietþ250 mg/kg Lf) and Lf 500 mg/kg (basal dietþ500 mg/kg Lf); n¼24 birds/treatment. An apparent metabolisable energy study was performed between d 25-32. 3. Lf did not affect growth rate or feed conversion in the period 0-21 d of age, nor performance or energy metabolism during the 7 d metabolism experiment which commenced at 25 d of age. 4. The profiles of caecal microbial communities were significantly different in birds given ZnB compared with birds given a diet with no additives, or supplemented with 250 mg/kg Lf. Birds given 250 mg/kg Lf also had a different microbial profile compared with birds given 500 mg/kg Lf. 5. In comparison to control birds, Lf treated birds showed some differences in the T cell proportions in caecal tonsil and spleen. No differences in ileal villus height, crypt depth or goblet cell proportions were observed amongst dietary treatments. 6. Whilst Lf had little effect on the measured parameters, the use of an integrated approach to study the influence of novel feed additives may facilitate a greater understanding of the relationships between nutrition, gut health and bird performance.
Keywords: Intestines
Goblet Cells
Animals
Chickens
Bacteria
Bacitracin
Lactoferrin
Anti-Bacterial Agents
Food Additives
Diet
Energy Metabolism
Polymorphism, Restriction Fragment Length
Animal Feed
Denaturing Gradient Gel Electrophoresis
Rights: © 2011 British Poultry Science Ltd
DOI: 10.1080/00071668.2011.607429
Appears in Collections:Animal and Veterinary Sciences publications
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