Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/7122
Citations
Scopus Web of ScienceĀ® Altmetric
?
?
Type: Journal article
Title: Somatic mutation of immunoglobulin V(H)6 genes in human infants
Author: Ridings, J.
Dinan, L.
Williams, R.
Roberton, D.
Zola, H.
Citation: Clinical and Experimental Immunology, 1998; 114(1):33-39
Publisher: WILEY
Issue Date: 1998
ISSN: 0009-9104
1365-2249
Abstract: Infants respond to antigen by making antibody that is generally of low affinity for antigen. Somatic hypermutation of immunoglobulin genes, and selection of cells expressing mutations with improved affinity for antigen, are the molecular and cellular processes underlying the maturation of antibody affinity. We have reported previously that neonates and infants up to 2 months of age, including individuals undergoing strong immunological challenge, show very few mutated V(H)6 sequences, with low mutation frequencies in mutated sequences, and little evidence of selection. We have now examined immunoglobulin genes from healthy infants between 2 and 10 months old for mutation and evidence of selection. In this age group, the proportion of V(H)6 sequences which are mutated and the mutation frequency in mutated sequences increase with age. There is evidence of selection from 6 months old. These results indicate that the process of affinity maturation, which depends on cognate T-B cell interaction and functional germinal centres, is approaching maturity from 6 months old.
Keywords: Humans; Immunoglobulin Variable Region; Complementarity Determining Regions; Mutation; Adult; Infant; Immunoglobulin alpha-Chains; Immunoglobulin Heavy Chains; Genetic Variation
RMID: 0030005693
DOI: 10.1046/j.1365-2249.1998.00694.x
Appears in Collections:Paediatrics publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.