Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||The role of zinc in genomic stability|
|Citation:||Mutation Research: Fundamental and Molecular Mechanisms of Mutagenesis, 2012; 733(1-2):111-121|
|Publisher:||Elsevier Science BV|
|Razinah Sharif, Philip Thomas, Peter Zalewski and Michael Fenech|
|Abstract:||Zinc (Zn) is an essential trace element required for maintaining both optimal human health and genomic stability. Zn plays a critical role in the regulation of DNA repair mechanisms, cell proliferation, differentiation and apoptosis involving the action of various transcriptional factors and DNA or RNA polymerases. Zn is an essential cofactor or structural component for important antioxidant defence proteins and DNA repair enzymes such as Cu/Zn SOD, OGG1, APE and PARP and may also affect activities of enzymes such as BHMT and MTR involved in methylation reactions in the folate-methionine cycle. This review focuses on the role of Zn in the maintenance of genome integrity and the effects of deficiency or excess on genomic stability events and cell death.|
Dose-Response Relationship, Drug
|Rights:||© 2011 Elsevier Ltd. All rights reserved.|
|Appears in Collections:||Aurora harvest 2|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.