Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/71244
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Type: Journal article
Title: The role of zinc in genomic stability
Author: Sharif, R.
Thomas, P.
Zalewski, P.
Fenech, M.
Citation: Mutation Research: Fundamental and Molecular Mechanisms of Mutagenesis, 2012; 733(1-2):111-121
Publisher: Elsevier Science BV
Issue Date: 2012
ISSN: 1386-1964
0027-5107
Statement of
Responsibility: 
Razinah Sharif, Philip Thomas, Peter Zalewski and Michael Fenech
Abstract: Zinc (Zn) is an essential trace element required for maintaining both optimal human health and genomic stability. Zn plays a critical role in the regulation of DNA repair mechanisms, cell proliferation, differentiation and apoptosis involving the action of various transcriptional factors and DNA or RNA polymerases. Zn is an essential cofactor or structural component for important antioxidant defence proteins and DNA repair enzymes such as Cu/Zn SOD, OGG1, APE and PARP and may also affect activities of enzymes such as BHMT and MTR involved in methylation reactions in the folate-methionine cycle. This review focuses on the role of Zn in the maintenance of genome integrity and the effects of deficiency or excess on genomic stability events and cell death.
Keywords: Cell Line
Telomere
Animals
Humans
Neoplasms
DNA Damage
Genomic Instability
Zinc
Trace Elements
Antioxidants
DNA Methylation
DNA Repair
Oxidative Stress
Dose-Response Relationship, Drug
Polymorphism, Genetic
Rights: © 2011 Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.mrfmmm.2011.08.009
Appears in Collections:Aurora harvest 2
Medicine publications

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