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https://hdl.handle.net/2440/71244
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Type: | Journal article |
Title: | The role of zinc in genomic stability |
Author: | Sharif, R. Thomas, P. Zalewski, P. Fenech, M. |
Citation: | Mutation Research: Fundamental and Molecular Mechanisms of Mutagenesis, 2012; 733(1-2):111-121 |
Publisher: | Elsevier Science BV |
Issue Date: | 2012 |
ISSN: | 1386-1964 0027-5107 |
Statement of Responsibility: | Razinah Sharif, Philip Thomas, Peter Zalewski and Michael Fenech |
Abstract: | Zinc (Zn) is an essential trace element required for maintaining both optimal human health and genomic stability. Zn plays a critical role in the regulation of DNA repair mechanisms, cell proliferation, differentiation and apoptosis involving the action of various transcriptional factors and DNA or RNA polymerases. Zn is an essential cofactor or structural component for important antioxidant defence proteins and DNA repair enzymes such as Cu/Zn SOD, OGG1, APE and PARP and may also affect activities of enzymes such as BHMT and MTR involved in methylation reactions in the folate-methionine cycle. This review focuses on the role of Zn in the maintenance of genome integrity and the effects of deficiency or excess on genomic stability events and cell death. |
Keywords: | Cell Line Telomere Animals Humans Neoplasms DNA Damage Genomic Instability Zinc Trace Elements Antioxidants DNA Methylation DNA Repair Oxidative Stress Dose-Response Relationship, Drug Polymorphism, Genetic |
Rights: | © 2011 Elsevier Ltd. All rights reserved. |
DOI: | 10.1016/j.mrfmmm.2011.08.009 |
Published version: | http://dx.doi.org/10.1016/j.mrfmmm.2011.08.009 |
Appears in Collections: | Aurora harvest 2 Medicine publications |
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