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Type: Journal article
Title: Biologic therapies in the metastatic colorectal cancer treatment continuum - applying current evidence to clinical practice
Author: Peeters, M.
Price, T.
Citation: Cancer Treatment Reviews, 2012; 38(5):397-406
Publisher: W B Saunders Co Ltd
Issue Date: 2012
ISSN: 0305-7372
Statement of
Marc Peeters and Timothy Price
Abstract: More therapeutic options are now available than ever before for patients with metastatic colorectal cancer (mCRC) and, as such, treatment decisions have become more complex. A multidisciplinary approach is, therefore, required to effectively manage these patients. In the past few years, many trials have reported on the value of combining biological agents, such as those targeting vascular endothelial growth factor A and epidermal growth factor receptors, with chemotherapy. However, despite the plethora of information now available, the optimal treatment strategy for patients with mCRC remains unclear. Indeed, the propensity of investigators to conduct clinical trials utilising a variety of chemotherapy backbones combined with the increased complexity of retrospectively incorporating analyses of genetic mutation status (e.g. KRAS and BRAF) have led to conflicting results for seemingly similar endpoints, particularly overall survival. As a result, guidelines that have been developed, whilst having some similarities, have distinct differences in terms of suggested therapeutic combinations. Therefore, here, we review and distil the currently available data reported from phase III trials of biologic agents in the first-, second- and third-line mCRC settings.
Keywords: Humans
Colorectal Neoplasms
Organoplatinum Compounds
ras Proteins
Proto-Oncogene Proteins B-raf
Vascular Endothelial Growth Factor A
Proto-Oncogene Proteins
Antineoplastic Combined Chemotherapy Protocols
Antibodies, Monoclonal
Proto-Oncogene Proteins p21(ras)
Antibodies, Monoclonal, Humanized
ErbB Receptors
Rights: © 2011 Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.ctrv.2011.08.002
Published version:
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