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Type: Journal article
Title: Circadian rhythms and fertility
Author: Kennaway, D.
Boden, M.
Varcoe, T.
Citation: Molecular and Cellular Endocrinology, 2012; 349(1):56-61
Publisher: Elsevier Sci Ireland Ltd
Issue Date: 2012
ISSN: 0303-7207
Statement of
David J. Kennaway, Michael J. Boden and Tamara J. Varcoe
Abstract: Circadian rhythms impact on a wide range of physiological systems and this impact extends to fertility, such that disruptions to timing systems can impact upon reproductive capacity. This is highlighted most obviously in mutant mouse models whereby deletion or mutation of single genes results not only in disrupted circadian rhythmicity, but also compromised male and female reproductive function. In this review, we discuss the presence of circadian clocks in female and male reproductive tissues and the role these clocks play in the generation of oestrus cycles, ovulation, sperm generation, implantation and the maintenance of pregnancy. Given the increased incidence of shiftwork and international travel which disrupt circadian rhythmicity, and the increasing prevalence of reproductive technologies whereby early embryo development occurs without external time cues, it is important for us to consider the role of circadian rhythms in fertility.
Keywords: Circadian rhythms; Clock genes; Period; Bmal1; Ovary; Testis
Rights: Crown Copyright © 2011 Published by Elsevier Ireland Ltd. All rights reserved.
RMID: 0020116817
DOI: 10.1016/j.mce.2011.08.013
Appears in Collections:Obstetrics and Gynaecology publications

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