Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/71332
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Type: Journal article
Title: A proposed model for economic evaluations of major depressive disorder
Author: Hajiali Afzali, H.
Karnon, J.
Gray, J.
Citation: European Journal of Health Economics, 2012; 13(4):501-510
Publisher: Springer
Issue Date: 2012
ISSN: 1618-7598
1618-7601
Statement of
Responsibility: 
Hossein Haji Ali Afzali, Jonathan Karnon and Jodi Gray
Abstract: In countries like UK and Australia, the comparability of model-based analyses is an essential aspect of reimbursement decisions for new pharmaceuticals, medical services and technologies. Within disease areas, the use of models with alternative structures, type of modelling techniques and/or data sources for common parameters reduces the comparability of evaluations of alternative technologies for the same condition. The aim of this paper is to propose a decision analytic model to evaluate longterm costs and benefits of alternative management options in patients with depression. The structure of the proposed model is based on the natural history of depression and includes clinical events that are important from both clinical and economic perspectives. Considering its greater flexibility with respect to handling time, discrete event simulation (DES) is an appropriate simulation platform for modelling studies of depression. We argue that the proposed model can be used as a reference model in modelbased studies of depression improving the quality and comparability of studies.
Keywords: Economic evaluation; decision modelling; depression; discrete event simulation
Rights: © Springer-Verlag 2011
RMID: 0020116808
DOI: 10.1007/s10198-011-0321-3
Appears in Collections:Public Health publications

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