Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/71476
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Type: | Journal article |
Title: | FOXP3 and FOXP3-regulated microRNAs suppress SATB1 in breast cancer cells |
Author: | McInnes, N. Sadlon, T. Brown, C. Pederson, S. Beyer, M. Schultze, J. McColl, S. Goodall, G. Barry, S. |
Citation: | Oncogene, 2012; 31(8):1045-1054 |
Publisher: | Nature Publishing Group |
Issue Date: | 2012 |
ISSN: | 0950-9232 1476-5594 |
Statement of Responsibility: | N McInnes, TJ Sadlon, CY Brown, S Pederson, M Beyer, JL Schultze, S McColl, GJ Goodall and SC Barry |
Abstract: | The transcription factor FOXP3 has been identified as a tumour suppressor in the breast and prostate epithelia, but little is known about its specific mechanism of action. We have identified a feed-forward regulatory loop in which FOXP3 suppresses the expression of the oncogene SATB1. In particular, we demonstrate that SATB1 is not only a direct target of FOXP3 repression, but that FOXP3 also induces two miRs, miR-7 and miR-155, which specifically target the 3′-UTR of SATB1 to further regulate its expression. We conclude that FOXP3-regulated miRs form part of the mechanism by which FOXP3 prevents the transformation of the healthy breast epithelium to a cancerous phenotype. Approaches aimed at restoring FOXP3 function and the miRs it regulates could help provide new approaches to target breast cancer. |
Keywords: | SATB1 FOXP3 microRNA gene regulation networks breast cancer tumour suppressor |
Rights: | © 2012 Macmillan Publishers Limited |
DOI: | 10.1038/onc.2011.293 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/565314 |
Published version: | http://dx.doi.org/10.1038/onc.2011.293 |
Appears in Collections: | Aurora harvest Paediatrics publications |
Files in This Item:
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hdl_71476.pdf | Accepted version | 1.4 MB | Adobe PDF | View/Open |
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