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Type: Journal article
Title: The fetal origins of obesity: early origins of altered food intake
Author: Muhlhausler, B.
Ong, Z.
Citation: Endocrine, Metabolic and Immune Disorders: Drug Targets, 2011; 11(3):189-197
Publisher: Bentham Science Publishers Ltd
Issue Date: 2011
ISSN: 1871-5303
Statement of
B.S. Muhlhausler and Z.Y. Ong
Abstract: There is now clear evidence from population-based and experimental animal studies that maternal obesity and maternal overnutrition, particularly excessive intake of high-fat and high-sugar diets, is associated with an increased risk of obesity and type 2 diabetes in the offspring. Whilst the physiological reasons for this association are still not fully understood, one of the key pathways appears to be the ability of exposure to an oversupply of energy, fat and sugar during critical windows of development to program an increased food intake in the offspring. This review will focus on our current understanding of the programming of food intake, with a focus on the importance of the maternal diet. Specifically, we will discuss how exposure to an increased energy supply before birth and in early infancy, and/or increased maternal intake of palatable foods alters the development of the systems regulating appetite and food preferences, and how these changes interact to promote excess consumption and thus predispose the offspring to weight gain and obesity.
Keywords: Programming
food preference
food intake
micro nutrients
fetal growth
maternal obesity
metabolic disease
cadriovascular diseases
Rights: Copyright © 2011 Bentham Science Publishers
DOI: 10.2174/187153011796429835
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Appears in Collections:Agriculture, Food and Wine publications
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