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Type: Journal article
Title: Overlapping motifs in the membrane-proximal region of cytokine receptor accessory and signaling subunits
Author: D'Andrea, R.
Sadlon, T.
Gonda, T.
Citation: Cytokine and Growth Factor Reviews, 2004; 15(2-3):83-85
Publisher: Elsevier Sci Ltd
Issue Date: 2004
ISSN: 1359-6101
Abstract: The membrane-proximal cytoplasmic region of cytokine receptors (CRs) is highly conserved and essential for receptor activation. In particular this region is essential for the activation of members of the Janus family of protein kinases (JAK) which results in initiation of receptor signaling. We have examined the sequence of this region in a number of CR signaling and accessory subunits with a view to better delineating motifs that play an important role in initiating receptor activity. Here, we have delineated two distinct proline-rich motifs in the membrane-proximal domains of cytokine receptors. Their configuration and distribution among CR subunits strongly suggest a model in which the two motifs act in a concerted manner to induce full receptor and JAK activation.
Keywords: Cytoplasm
Receptors, Cytokine
Amino Acid Sequence
Amino Acid Motifs
Consensus Sequence
Molecular Sequence Data
Protein-Tyrosine Kinases
DOI: 10.1016/j.cytogfr.2004.02.001
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Appears in Collections:Aurora harvest
Paediatrics publications

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