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Type: Journal article
Title: Overlapping motifs in the membrane-proximal region of cytokine receptor accessory and signaling subunits
Author: D'Andrea, R.
Sadlon, T.
Gonda, T.
Citation: Cytokine & Growth Factor Reviews, 2004; 15(2-3):83-85
Publisher: Elsevier Sci Ltd
Issue Date: 2004
ISSN: 1359-6101
Abstract: The membrane-proximal cytoplasmic region of cytokine receptors (CRs) is highly conserved and essential for receptor activation. In particular this region is essential for the activation of members of the Janus family of protein kinases (JAK) which results in initiation of receptor signaling. We have examined the sequence of this region in a number of CR signaling and accessory subunits with a view to better delineating motifs that play an important role in initiating receptor activity. Here, we have delineated two distinct proline-rich motifs in the membrane-proximal domains of cytokine receptors. Their configuration and distribution among CR subunits strongly suggest a model in which the two motifs act in a concerted manner to induce full receptor and JAK activation.
Keywords: Cytoplasm; Animals; Humans; Proline; Receptors, Cytokine; Amino Acid Sequence; Amino Acid Motifs; Consensus Sequence; Molecular Sequence Data; Protein-Tyrosine Kinases
RMID: 0020041701
DOI: 10.1016/j.cytogfr.2004.02.001
Appears in Collections:Paediatrics publications

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