Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Overlapping motifs in the membrane-proximal region of cytokine receptor accessory and signaling subunits|
|Citation:||Cytokine & Growth Factor Reviews, 2004; 15(2-3):83-85|
|Publisher:||Elsevier Sci Ltd|
|Abstract:||The membrane-proximal cytoplasmic region of cytokine receptors (CRs) is highly conserved and essential for receptor activation. In particular this region is essential for the activation of members of the Janus family of protein kinases (JAK) which results in initiation of receptor signaling. We have examined the sequence of this region in a number of CR signaling and accessory subunits with a view to better delineating motifs that play an important role in initiating receptor activity. Here, we have delineated two distinct proline-rich motifs in the membrane-proximal domains of cytokine receptors. Their configuration and distribution among CR subunits strongly suggest a model in which the two motifs act in a concerted manner to induce full receptor and JAK activation.|
|Keywords:||Cytoplasm; Animals; Humans; Proline; Receptors, Cytokine; Amino Acid Sequence; Amino Acid Motifs; Consensus Sequence; Molecular Sequence Data; Protein-Tyrosine Kinases|
|Appears in Collections:||Paediatrics publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.