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Type: Journal article
Title: Multiscale entropy and detrended fluctuation analysis of QT interval and heart rate variability during normal pregnancy
Author: Baumert, M.
Javorka, M.
Seeck, A.
Faber, R.
Sanders, P.
Voss, A.
Citation: Computers in Biology and Medicine, 2012; 42(3):347-352
Publisher: Pergamon-Elsevier Science Ltd
Issue Date: 2012
ISSN: 0010-4825
Statement of
Mathias Baumert, Michal Javorka, Andrea Seeck, Renaldo Faber, Prashanthan Sanders, Andreas Voss
Abstract: Pregnancy leads to physiological changes in various parameters of the cardiovascular system. The aim of this study was to investigate longitudinal changes in the structure and complexity of heart rate variability (HRV) and QT interval variability during the second half of normal gestation. We analysed 30-min high-resolution ECGs recorded monthly in 32 pregnant women, starting from the 20th week of gestation. Heart rate and QT variability were quantified using multiscale entropy (MSE) and detrended fluctuation analyses (DFA). DFA of HRV showed significantly higher scaling exponents towards the end of gestation (p<0.0001). MSE analysis showed a significant decrease in sample entropy of HRV with progressing gestation on scales 1-4 (p<0.05). MSE analysis and DFA of QT interval time series revealed structures significantly different from those of HRV with no significant alteration during the second half of gestation. In conclusion, pregnancy is associated with increases in long-term correlations and regularity of HRV, but it does not affect QT variability. The structure of QT time series is significantly different from that of RR time series, despite its close physiological dependence.
Keywords: Pregnancy
QT variability
Heart rate variability
Multiscale analysis
Detrended fluctuation analysis
Rights: Copyright © 2011 Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.compbiomed.2011.03.019
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